苦参碱及其类似物的结构修饰研究进展  

Advances in structural modification of matrine and its analogues

作　　者：张晓雯 李凌宇[2] 尚海[2,3] 邹忠梅 ZHANG Xiao-wen;LI Ling-yu;SHANG Hai;ZOU Zhong-mei(Center of Pharmaceutical Engineering Technology Research,College of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]哈尔滨商业大学药学院药物工程技术研究中心,黑龙江哈尔滨150076 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193 [3]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中草药》2019年第23期5892-5900,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目（81502929）;中国医学科学院医学与健康科技创新工程经费资助（2016-I2M-3-015）

摘　　要：苦参碱来源于豆科植物苦参Sophora flavescens、苦豆子Sophora alopecuroides等中药,具有多种药理作用,资源丰富。槐果碱是苦参碱D环C-13,14位脱氢的结构类似物,由于其结构的高度相似性,槐果碱同样表现出广泛的药理活性。但苦参碱和槐果碱的药理活性不强,对此开展了大量的结构改造工作。以修饰位点分类,就苦参碱及槐果碱的结构改造及衍生物活性研究进展进行综述,并对其今后发展趋势进行展望。Matrine is pyrrolizidine alkaloid derived from Chinese materia medica such as Sophora flavescens and Sophora alopecuroides.It has a wide range of pharmacological effects and abundant resources.Sophocarpine is a D ring 13,14-position dehydrogenation analogue of matrine.Due to the high similarity in structure,sophocarpine also exhibits a wide range of pharmacological activities.However,the pharmacological activities of matrine and sophocarpine are not strong,so a great scale of structural modification were carried out.In this paper,the structural modification and derivative activity of matrine and sophoridine were reviewed according to the modification sites classification,and the future development trend was prospected.

关 键 词：苦参碱 槐果碱 衍生物 结构改造 生物活性 

分 类 号：R285[医药卫生—中药学]