海洋药物研究开发进展  

Recent progress in research and development of marine drugs

作　　者：王成[1,2] 张国建 刘文典[1] 杨新雨 朱妮 申静敏 王志成 刘杨 程珊 于广利 管华诗 WANG Cheng;ZHANG Guo-Jian;LIU Wen-dian;YANG Xin-yu;ZHU Ni;SHEN Jing-min;WANG Zhi-cheng;LIU Yang;CHENG Shan;YU Guang-li;GUAN Hua-shi(Key Laboratory of Marine Drugs,Ministry of Education,Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology,Qingdao 266237,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,山东省糖科学与糖工程重点实验室,医药学院,山东青岛266003 [2]青岛海洋科学与技术试点国家实验室海洋药物与生物制品功能实验室,山东青岛266237

出　　处：《中国海洋药物》2019年第6期35-69,共35页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目（31670811,81991522）;青岛市应用基础研究专项（18-2-2-73-jch）;中国海洋大学专项基金项目（201964018）资助

摘　　要：新颖结构和重要生物活性天然产物的发现是创新药物开发的关键要素。海洋生物资源以其多样性、复杂性、特殊性成为新药研发中先导化合物的重要来源,截止目前基于海洋天然产物或其衍生物开发而成功上市的药物有17种,进入Ⅲ期、Ⅱ期、Ⅰ期临床研究的活性物质分别有8、12、8种,而折戟于临床阶段的有4种;本文对其生物来源、作用机理、临床研究进展作了简要概述,期待海洋药物学科能更快、更好地发展,产生更多新药,为人类重大疾病的治疗做出重大贡献。The structural novelty and biological activity of chemical entities have been emphasized as major concerns in developing innovative drugs.Marine biological resources have become an important source of leading compounds in new drug research and development due to their diversity,complexity and specialarity.Up to now,there are up to 17 clinical available marine drugs having been developed from marine natural products or their derivatives,together with 8,12 and 8 leading compounds under phase III,II and I clinical study,respectively,while 4 kinds of drug candidates failed in the clinical stage.In this paper,the biological sources,mode of action and the progress of clinical studies are briefly reviewed.It is expected to benefit the marine drug research,accelerate marine drug development pipelines and provide efficient medication treatments to the combat fighting against major diseases threatening human health.

关 键 词：海洋天然产物 海洋药物 生物来源 作用机理 临床 

分 类 号：R931.77[医药卫生—生药学]