针刺太冲、太溪对自发性高血压大鼠下丘脑GLUT1和GLUT3表达及相关能量代谢的影响  

Effects of Acupuncture at Taichong(LR3) and Taixi(KI3) on GLUT1 and GLUT3 Expressions and Related Energy Metabolism in Hypothalamus of Spontaneous Hypertension Rats

作　　者：吴金建 张笑 段玉婷 郭鸿基 汪花 唐纯志 WU Jinjian;ZHANG Xiao;DUAN Yuting;GUO Hongji;WANG Hua;TANG Chunzhi(Acupuncture-Moxibustion and Rehibilitation Clinical Medical School,Guangzhou University of Chinese Medicine,Guangzhou 510000,Guangdong,China)

机构地区：[1]广州中医药大学针灸康复临床医学院

出　　处：《中华中医药学刊》2019年第12期2924-2928,I0043,I0044,共7页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(2012CB518504)

摘　　要：目的:观察针刺太冲、太溪对自发性高血压大鼠下丘脑GLUT1和GLUT3表达及相关能量代谢的影响,探讨针刺治疗自发性高血压的机制。方法:自发性高血压大鼠按随机数字表法分为模型组、非穴组、冲溪组,并设置正常组对照,均为12只,采用免疫组化染色后去检测大鼠下丘脑GLUT1和GLUT3表达水平。结果:4周治疗后,与正常组、冲溪组比较,模型组大鼠脑皮质GLUT1、GLUT3表达水平均显著降低,与非穴组比较,冲溪组大鼠GLUT1、GLUT3表达水平均升高。结论:针刺太冲、太溪降低自发性高血压大鼠血压,其机制可能与升高大鼠下丘脑GLUT1、 GLUT3的表达有关。Objective:To observe the effects of acupuncture at Taichong(LR3)and Taixi(KI3)on GLUT1 and GLUT3 expressions and related energy metabolism in hypothalamus of spontaneous hypertension rats.Methods:Spontaneous hypertension rats were randomly divided into the model group(n=12),the Chong-Xi group(n=12),the sham point group(n=12)and the control group(n=12).Rats in the Chong-Xi group and the sham point group were needled once per day for 5 min,6 days in one week,and 4 weeks in all.Immunochemistry staining was used to identify the expression levels of the GLUT1 and GLUT3.Results:After the 4-week acupuncture intervention,the GLUT1 and GLUT3 of the model group were lower than those of the Chong-Xi group and the control group.Compared with the sham point group,the expression levels of the GLUT1 and GLUT3 were improved in the Chong-Xi group.Conclusion:Acupuncture at Taichong(LR3)and Taixi(KI3)can lower blood pressure of spontaneous hypertension rats and its mechanism may be related to the regulation of the expressions of GLUT1 and GLUT3 in hypothalamus.

关 键 词：太冲 太溪 自发性高血压 葡萄糖转运蛋白1 葡萄糖转运蛋白3 

分 类 号：R245.3[医药卫生—针灸推拿学]