6b,11b-二羟基-9,9-二甲基-7-对甲氧基苯基-8,9,10,11b-四氢化6bH-苊并[1,2-b]吲哚-11(7H)-酮的合成和晶体结构  

Synthesis and crystal structure of 6b,11b-dihydroxy-7-aryl-8,9,10,11b-tetrahydroacenaphtho[1,2-b]indol-11(7H)-one

作　　者：杨芳[1] 林伟 史达清[3] YANG Fang;LIN Wei;SHI Da-qing(Suzhou Institute of Construction and Communication,Suzhou 215104,China;School of Chemical and Environmental Engineering,Jiangsu University of Technology,Changzhou 213001,China;College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州建设交通高等职业技术学校,江苏苏州215104 [2]江苏理工学院化学与环境工程学院,江苏常州213001 [3]苏州大学材料与化学化工学部,江苏苏州215123

出　　处：《分子科学学报》2019年第6期497-502,I0003,共7页Journal of Molecular Science

基　　金：江苏省高校自然科学重大资助项目(15KJA150006)

摘　　要：利用L-脯氨酸催化的烯胺酮(1)与苊醌(2)的加成、环化串联反应,合成得到了6b,11b-二羟基-9,9-二甲基-7-对甲氧基苯基-8,9,10,11b-四氢化6bH-苊并[1,2-b]吲哚-11(7 H)-酮(3).标题化合物的结构通过单晶X射线衍射法确定,晶体属于单斜晶系,空间群C2/c,相对分子质量Mr=427.48,晶胞参数a=3.1870(6)nm,b=0.97422(19)nm,c=1.3648(3)nm,V=4.2344(15)nm3,Z=8,晶胞密度Dc=1.341g·cm-3,吸收系数μ=0.090mm-1,单胞中电子的数目F(000)=1808.晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终的偏离因子为R=0.0957,wR=0.2724.在晶体结构中2个羟基处于顺式,通过分子间氢键形成二聚体.The title compound 6 b,11 b-dihydroxy-7-aryl-8,9,10,11 b-tetrahydroacenaphtho[1,2-b]indol-11(7 H)-one derivatives(3)has been synthesized by the tandem reaction of enaminones and acenaphthequinone catalyzed by L-proline.The structure of compound3 was determined by single crystal X-ray diffraction analysis.The crystal is monoclinic,space group C2/c,with Mr=427.48,a=3.1870(6)nm,b=0.97422(19)nm,c=1.3648(3)nm,V=4.2344(15)nm3,Z=8,Dc=1.341 g·cm-3,μ=0.090 mm-1,F(000)=1808.The structure was solved by direct methods and refined by full-matrix least squares method to the final R=0.0957,wR=0.2724.X-ray analysis reveals that two hydroxy groups are in cis form.The dimer was formed by intermolecular hydrogen bonds in the molecule.

关 键 词：四氢化苊并[1 2-d]吲哚-11(7H)-酮 合成 晶体结构 

分 类 号：O626[理学—有机化学]