Wüstite-type Fe0.78Mn0.22O nanocubes:A new class for high-sensitive T2-weighted magnetic resonance imaging agent  

作　　者：Huawei Rong Haihua Hu Jian Zhang Jianjun Wang Mu Zhang Gaowu Qin Yanhui Zhang Xuefeng Zhang 

机构地区：[1]Key Laboratory for Anisotropy and Texture of Materials(MOE),School of Materials Science and Engineering,Northeastern University,Shenyang,110819,China [2]Shenyang Northeastern Institute of Metal Materials Co.,Ltd,Shenyang,110108,China [3]Institute of Advanced Magnetic Materials,Hangzhou Dianzi University,Hangzhou,310012,China

出　　处：《Journal of Materials Science & Technology》2019年第11期2485-2493,共9页材料科学技术（英文版）

基　　金：supported financially by the National Natural Science Foundation of China (Nos.51471045,51401049 and 51471048);the National 1000-Plan for Young Scholars and the Start-up Funding from the Northeastern University of China;the Fundamental Research Funds for the Central Universities (No. N160208001)

摘　　要：Wüstite-type Fe(0.78)Mn(0.22)O nanocubes,with a uniform size of^10 nm in edge length,have been synthesized by thermal-decomposition approach.The nanocubes exhibited superparamagnetic properties at room temperature,associated with a magnetization of 12.6 emu/g.These Fe(0.78)Mn(0.22)O nanocubes present transversal(r2)and longitudinal(r1)relaxivities of 325.9 and 0.518 mM^-1 s^-1 at 7 T for water protons.The ratio of the r2/r1(629.2)ranks them being the highest sensitivity(r2/r1)comparable to currently reported T2-weighted magnetic resonance imaging(MRI)agents.Meanwhile,the Fe(0.78)Mn(0.22)O nanocubes were functionalized and demonstrated to be biocompatible when attached to the surface of mesenchymal stem cells,therefore showing the promise as a new class of MRI agents in clinic applications.Wüstite-type Fe0.78Mn0.22O nanocubes,with a uniform size of～10 nm in edge length,have been synthesized by thermal-decomposition approach.The nanocubes exhibited superparamagnetic properties at room temperature,associated with a magnetization of 12.6 emu/g.These Fe0.78Mn0.22O nanocubes present transversal（r2） and longitudinal（r1） relaxivities of 325.9 and 0.518 mM-1 s-1 at 7 T for water protons.The ratio of the r2/r1（629.2） ranks them being the highest sensitivity（r2/r1） comparable to currently reported T2-weighted magnetic resonance imaging（MRI） agents.Meanwhile,the Fe0.78Mn0.22O nanocubes were functionalized and demonstrated to be biocompatible when attached to the surface of mesenchymal stem cells,therefore showing the promise as a new class of MRI agents in clinic applications.

关 键 词：Magnetic resonance imaging(MRI) SUPERPARAMAGNETISM FeMn oxides NANOCUBES 

分 类 号：TQ421.7[化学工程] TB383.1[一般工业技术—材料科学与工程]