Highly oxygenous trichilin-type limonoids from Trichilia sinensis  

作　　者：AN Fa-Liang YIN Yong LUO Jun KONG Ling-Yi 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University

出　　处：《Chinese Journal of Natural Medicines》2019年第12期912-917,共6页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.31470416);the Outstanding Youth Fund of the Basic Research Program of Jiangsu Province(No.BK20160077);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63)

摘　　要：Six new trichilin-type limonoids(1-6)with C-19/29 lactol or acetal bridge and a new ring intact limonoid(7)were isolated from the desiccative ripe fruits of Trichilia sinensis.Their structures were determined by extensive spectroscopic methods including 1 H NMR,13 C NMR,HSQC,HMBC,ROESY experiments as well as HRESI-MS data.All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B(SRB)method.Compound 7 showed weak inhibitory activity in Hela cell line at 40μmol·L^-1.Six new trichilin-type limonoids(1-6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid(7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including 1 H NMR, 13 C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B(SRB) method. Compound 7 showed weak inhibitory activity in Hela cell line at 40 μmol·L-1.

关 键 词：Trichilin-type limonoids Trichilia sinensis Cytotoxic activity 

分 类 号：R284[医药卫生—中药学]