Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla  

作　　者：WANG Yue GUO Qing-Lan LI Ruo-Fei XU Cheng-Bo ZHU Cheng-Gen SHI Jian-Gong 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

出　　处：《Chinese Journal of Natural Medicines》2019年第12期928-934,共7页中国天然药物（英文版）

基　　金：supported by the National Natural Sciences Foundation of China(Nos.81630094,21732008,and 81730093);CAMS Innovation Fund for Medical Science of China(Nos.2017-I2M-3-010 and 2016-I2M-1-010);the Drug Innovation Major Project(No.2018ZX09711001-001-001)

摘　　要：Two new folate-derived analogues,named uncarophyllofolic acids A(1)and B(2),respectively,were isolated from the Uncaria rhynchophylla hook bearing stem(Gouteng in Chinese).The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey’s derivatization,along with comparison of their specific rotation and Cotton effect(CE)data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism(ECD)spectra.A plausible biosynthetic pathway of 1 and 2,associating to folate metabolism and the previously reported orychophragines A-C from Orychophragmus violaceus,is discussed.Two new folate-derived analogues, named uncarophyllofolic acids A(1) and B(2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem(Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey’s derivatization, along with comparison of their specific rotation and Cotton effect(CE) data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism(ECD) spectra. A plausible biosynthetic pathway of 1 and 2, associating to folate metabolism and the previously reported orychophragines A-C from Orychophragmus violaceus, is discussed.

关 键 词：RUBIACEAE Uncaria rhynchophylla Folate derivative Uncarophyllofolic acid Folate metabolism 

分 类 号：R284[医药卫生—中药学]