Anti-HIV lignans from Justicia procumbens  

作　　者：XU Xin-Ya WANG Dong-Ying KU Chuen-Fai ZHAO Yang CHENG Han LIU Kang-Lun RONG Li-Jun ZHANG Hong-Jie 

机构地区：[1]School of Chinese Medicine,Hong Kong Baptist University,Hong Kong SAR,China [2]Institute of Marine Drugs,Guangxi University of Chinese Medicine,Guangxi 530200,China [3]College of Food Science and Technology,Henan University of Technology,Zhengzhou 450001,China [4]Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago,IL 60612,United States

出　　处：《Chinese Journal of Natural Medicines》2019年第12期945-952,共8页中国天然药物（英文版）

基　　金：supported by the Research Grants Council of the Hong Kong Special Administrative Region,China(Nos.HKBU12103618 and HKBU12103917);the Research Grants Council of the Hong Kong Baptist University(HKBU);Interdisciplinary Research Matching Scheme(No.RC-IRMS/15-16/02);the Hong Kong Scholars Program Foundation(No.XJ2015047);Mr.Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund(WANG Dong-Ying)

摘　　要：Twenty-one lignans including three new ones(1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1 D and 2 D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate(13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L^-1 and a selective index(SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A(3) and diphyllin(8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95(SI > 6.2) and 0.38 μmol·L^-1(SI = 5.3), respectively.Twenty-one lignans including three new ones(1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1 D and 2 D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate(13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L-1 and a selective index(SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A(3) and diphyllin(8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95(SI > 6.2) and 0.38 μmol·L-1(SI = 5.3), respectively.

关 键 词：Justicia procumbens Antiviral plant Lignans Anti-HIV-1 activity 

分 类 号：R284[医药卫生—中药学]