Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana  

作　　者：WANG Yuan LIN Jing WANG Qi SHANG Kun PU De-Bing ZHANG Rui-Han LI Xiao-Li DAI Xiao-Chang ZHANG Xing-Jie XIAO Wei-Lie 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University

出　　处：《Chinese Journal of Natural Medicines》2019年第12期953-962,共10页中国天然药物（英文版）

基　　金：supported by Yunnan Applicative and Basic Research Program(Nos.2018FY001 and 2018FA048);the National Natural Science Foundation of China(Nos.81422046,81860615 and 21762048);the Foundation of Yunnan Educational Committee(No.2018JS002);the Natural Science Foundation of Yunnan University(No.2017YDQN03);the Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education(No.2017KF02);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);Project of Innovative Research Team of Yunnan Province to XIAO Wei-Lie

摘　　要：Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids,cathayanalactones A-F(1-6),together with seven analogues(7-13).Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses.Compounds 1,2,3,7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A-F(1-6), together with seven analogues(7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

关 键 词：Callicarpa cathayana Clerodane diterpenoids Nitric oxide Anti-inflammatory activity 

分 类 号：R284[医药卫生—中药学]