蒲滑散对实验大鼠慢性肾衰的作用研究  

Study of the Effects of Puhuasan on Chronic Renal Failure in Experimental Rats

作　　者：徐为公 徐鹏[2] 周立冬 XU Weigong;XU Peng;ZHOU Lidong(Former:Medical College of Chinese People's Armed Police Forces,Now:Tianjin YangQuan Medical Device Co.,Ltd.,Tianjin 300050,China;Tianjin Centei of Disease Control and Prevetion,Tianjin 300011,China;Tianjin YangQuan Medical Device Co.,Ltd.,Tianjin 300050,China)

机构地区：[1]原中国人民武装警察部队医学院,现天津市阳权医疗器械有限公司,天津300050 [2]天津市疾病预防控制中心,天津300011 [3]天津市阳权医疗器械有限公司,天津300050

出　　处：《实验动物科学》2019年第5期69-72,共4页Laboratory Animal Science

基　　金：天津市创新药物和医疗器械科技重大专项(No.19ZXYXSY00030)

摘　　要：目的 研究蒲滑散对大鼠慢性肾衰的作用。方法 采用Platt法诱发慢性肾衰大鼠模型,观察蒲滑散对血肌酐(Scr)、尿素氮(BUN)、血钙(Ca)、血磷(P)、甲状旁腺素(PTH)、中分子物质(MMS)的作用及肾脏病理学改变。结果 蒲滑散可明显改善大鼠肾脏病变,恢复肾脏功能,纠正高磷低钙血症,抑制PTH和MMS。结论 蒲滑散是治疗尿毒症的有效方药之一,其改善患者的临床症状与降低慢性肾功能衰竭(CRF)毒素潴留有关。Objective To study the effects of Puhuasan on chronic renal failure in rats.Method The rats were induced into chronic renal failure(CRF)by Platt,the Serum indexes like creatinine(Scr)、Urea nitrogen(BUN)、calcium(Ca)N phosphorus(P)A Parathyroid hormone(PTH)and middle molecule substence(MMS)were tested.Result The result showed that the function of renal were improved,high phosphorus and low calcium levels were adjusted,PTH and MMS were inhibited by Puhuasan.Conclusion Puhuasan is one of effective medicine to cure uremia,it's function may be connected with improving the clinical symptoms and reducing toxin in CRF.

关 键 词：蒲滑散 慢性肾功能衰竭 大鼠 

分 类 号：R285.5[医药卫生—中药学]