帕米膦酸二钠合成工艺路线研究  

Study on the Synthesis Process of Pamidronate Disodium

作　　者：毛辉 朱健 陈鹤京 朱惠洪[1] 刘振香[1] 郑柏勤[1] 盛贻林[1] 潘滔[1] Mao Hui;Zhu Jian;Chen Hejing;Zhu Huihong;Liu Zhenxiang;Zheng Baiqin;Sheng Yilin;Pan Tao(Jinhua Vocational and technical college,Jinhua 321007,China;Zhejiang otokang Pharmaceutical Group Co.,Ltd.,Jinhua321053,China)

机构地区：[1]金华职业技术学院,浙江金华321007 [2]浙江奥托康制药集团股份有限公司,浙江金华321053

出　　处：《山东化工》2019年第24期5-6,共2页Shandong Chemical Industry

基　　金：金华市科技计划项目(编号:2018-4-105)

摘　　要：选择合适的反应物的投料比不仅可以加快反应速率,更能提高产物的选择性。本文通过对熔融法合成帕米膦酸二钠的合成工艺进行研究,发现当选择一定比例的三氯氧磷和五氯化磷的混合物做试剂,调整原料与试剂的加入量、回流时间和水解时间,可以提高目标产物的收率。在帕米膦酸析晶过程中,采用自然析晶的技术方法,减少了杂质的析出,提高了其纯度。本文对帕米膦酸二钠合成路线的优化设计,符合当前"绿色化学"的理念要求。The suitable ratio of reactants can accelerate reaction rate as well as promote the selectivity of the product.Based on the research of synthesis of pamidronate disodium by molten state method,the yield of target product can be improved by selecting a certain proportion of POCl3 and PCl5 as mixed reagent,as well as adjusting the ratio of raw material and mixed reagent together with reflux time and hydrolysis time.During the precipitation of pamidronate,the technology of natural crystallization method can decrease the impurity and increase the purity.The optimal design of the synthetic route of the disodium param acid disodium meets the current concept of "green chemistry".

关 键 词：帕米膦酸二钠 熔融法 催化剂 绿色化学 

分 类 号：TQ463.6[化学工程—制药化工]