地藤痹痛颗粒对类风湿关节炎患者血清基质金属蛋白酶的影响  

Effect of Ditengbitong Granule on Serum Matrix Metalloproteinase in Patients with Rheumatoid Arthritis

作　　者：安晓蓓 刘进子[1] 付素兰[1] 张磊 高杨 AN Xiaobei;LIU Jinzi;FU Sulan;ZHANG Lei;GAO Yang(Shijiazhuang Third Hospital,Shijiazhuang,Hebei,China 050011;Hebei Food and Drug Administration,Shijiazhuang,Hebei,China 050000)

机构地区：[1]河北省石家庄市第三医院,河北石家庄050011 [2]河北省食品药品监督管理局,河北石家庄050000

出　　处：《中国药业》2020年第2期55-57,共3页China Pharmaceuticals

基　　金：2018年河北省医学科学研究重点课题[20181049]

摘　　要：目的探讨地藤痹痛颗粒治疗类风湿关节炎(RA)的效果及对血清基质金属蛋白酶(MMP)水平的影响。方法选取医院RA住院患者100例,随机分为对照组和研究组,各50例。两组患者均采用常规抗风湿药物(DMARDs)治疗,口服甲氨蝶呤片;研究组患者加用地藤痹痛颗粒。结果与对照组相比,研究组C反应蛋白、血沉水平下降显著(P <0. 05);治疗24周后,研究组各项MMP指标下降程度更显著(P <0. 05),压痛、肿胀关节数和28个关节疾病活动度评分显著降低(P <0. 05),ACR50和ACR70病情缓解比例更高(P <0. 05);研究组的疗效优于对照组,且与调控MMP的水平具有相关性。结论地藤痹痛颗粒可有效提高RA的疗效,其作用机制可能是通过调控患者血清中MMP-3,MMP-9,MMP-13水平而改善病情。Objective To investigate the effect of Ditengbitong Granules on rheumatoid arthritis( RA) and its effect on the level of serum matrix metalloproteinase( MMP). Methods A total of 100 patients with RA in the hospital were selected and randomly divided into control group and study group,50 cases in each group. Both groups were treated with anti-rheumatic drugs( DMARDs);methotrexate was orally administered. On the basis of the control group,the study group was added with Ditengbitong Granules. Results Compared with the control group,the study group could reduce the level of C-reactive protein( CRP) and erythrocyte sedimentation rate( ESR) more effectively( P < 0. 05). After 24 weeks of treatment,the MMP index of the study group decreased more significantly( P < 0. 05),the number of tender and swollen joints and disease activity score( DAS) 28 score decreased more significantly( P < 0. 05),and the remission rate of American College of Rheumatology( ACR) 50 and ACR70 was significantly higher( P < 0. 05). The curative effect of the study group was better than that of the control group,and it was related to the level of MMP regulation. Conclusion Ditengbitong Granules can effectively improve the efficacy of RA,and its mechanism of action may be to improve the condition by regulating the levels of MMP-3,MMP-9,and MMP-13 in the serum of RA patients.

关 键 词：地藤痹痛颗粒 类风湿关节炎 基质金属蛋白酶 临床疗效 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]