过敏性紫癜肾炎患儿血清IL-16、IL-18、IGF-1及IGFBP-3水平变化及临床意义  

Changes of serum IL-16, IL-18, IGF-1, and IGFBP-3 levels in children with Henoch-Sch?nlein purpura nephritis and their clinical significance

作　　者：秦艳妮 党清华 景芳丽 王?敏 QIN Yan-ni;DANG Qing-hua;JING Fang-li;WANG Yan-min(Department of Pediatrics,the Central Hospital of Xi'an City,Xi'an 710061,Shaanxi,CHINA;Department of Pediatrics,the Tianyou Hospital of Xi'an City,Xi'an 710061,Shaanxi,CHINA)

机构地区：[1]西安市中心医院儿科 [2]西安市天佑医院儿科

出　　处：《海南医学》2020年第1期31-34,共4页Hainan Medical Journal

摘　　要：目的探究过敏性紫癜肾炎患儿血清白细胞介素-16(IL-16)、白细胞介素-18(IL-18)、胰岛素一号增长因子(IGF-1)及胰岛素样生长因子结合蛋白-3(IGFBP-3)水平变化及临床意义。方法选取2016年1月至2019年1月西安市中心医院儿科收治的过敏性紫癜患儿(HSP组)38例及过敏性紫癜性肾炎患儿(HSPN组)46例作为研究对象,以同期在我院体检的40例健康儿童作为对照组。其中HSPN组患儿按照国际儿童肾病学会病理分级标准分为Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级4个亚组。比较各大组受检者的血清IL-16、IL-18、IGF-1及IGFBP-3水平,并分析肾炎患儿IL-16、IL-18、IGF-1、IGFBP-3水平与病理分级的相关性。结果HSPN组患儿的血清IL-16、IL-18、IGF-1、IGFBP-3水平分别为(134.22±26.82)ng/L、(263.5±36.15)ng/L、(0.95±0.51)ng/L、(0.86±0.50)ng/L,明显高于HSP组的(106.63±18.19)ng/L、(190.4±32.92)ng/L、(0.64±0.49)ng/L、(0.62±0.38)ng/L,而HSP组患儿的血清IL-16、IL-18、IGF-1、IGFBP-3水平明显高于对照组的(64.85±13.38)ng/L、(102.3±25.34)ng/L、(0.31±0.19)ng/L、(0.43±0.23)ng/L,差异均有统计学意义(P<0.05);肾炎Ⅳ级、Ⅲ级、Ⅱ级、Ⅰ级患儿血清IL-16、IL-18、IGF-1、IGFBP-3水平分别为(154.22±26.82)ng/L、(279.5±10.28)ng/L、(1.31±0.26)ng/L、(1.47±0.36)ng/L;(117.27±8.20)ng/L、(210.45±10.92)ng/L、(0.98±0.12)ng/L、(0.87±0.24)ng/L;(92.14±6.54)ng/L、(160.46±8.49)ng/L、(0.84±0.17)ng/L、(0.69±0.23)ng/L;(67.36±4.38)ng/L、(105.34±6.33)ng/L、(0.39±0.02)ng/L、(0.48±0.05)ng/L,且肾炎Ⅳ级患者IL-16、IL-18、IGF-1、IGFBP-3水平明显高于肾炎Ⅲ级,肾炎Ⅲ级明显高于肾炎Ⅱ级,肾炎Ⅱ级明显高于肾炎Ⅰ级,差异均有统计学意义(P<0.05);相关性分析结果显示,肾炎患儿血清IL-16、IL-18、IGF-1、IGFBP-3水平与病理分级呈正相关(r=0.946,、0.949、0.833、0.804,P<0.05)。结论HSPN患儿血清IL-16、IL-18、IGF-1及IGFBP-3水平均上升,并随着肾脏损伤程度的加重呈上�Objective To investigate the changes and clinical significance of serum IL-16,IL-18,IGF-1,and IGFBP-3 levels in children with Henoch-Schonlein purpura(HSP)nephritis(HSPN).Methods From January 2016 to January 2019,38 children with Henoch-Schonlein purpura(HSP group)and 46 children with Henoch-Schonlein purpura nephritis(HSPN group)who admitted to Department of Pediatrics,the Central Hospital of Xi'an City,were selected as the study subjects,and 40 healthy children who underwent physical examination in the same hospital during the same period were selected as the control group.The HSPN group was divided into four subgroups according to the pathological grading criteria of the International Pediatric Nephrology Association(IPNA):gradeⅠ,gradeⅡ,grade Ⅲ and grade Ⅳ.The serum levels of interleukin-16(IL-16),interleukin-18(IL-18),insulin-like growth factor I(IGF-1)and insulin-like growth factor binding protein-3(IGFBP-3)were compared in each group,and the correlation between the levels of IL-16,IL-18,IGF-1,and IGFBP-3 and pathological types was analyzed.Results The levels of IL-16,IL-18,IGF-1,and IGFBP-3 in the HSPN group were(134.22±26.82)ng/L,(263.5±36.15)ng/L,(0.95±0.51)ng/L,(0.86±0.50)ng/L,respectively,which were significantly higher than corresponding(106.63±18.19)ng/L,(190.4±32.92)ng/L,(0.64±0.49)ng/L,(0.62±0.38)ng/L in the HSP group(all P<0.05);the levels of IL-16,IL-18,IGF-1,and IGFBP-3 in the HSP group were also significantly higher than corresponding(64.85±13.38)ng/L,(102.3±25.34)ng/L,(0.31±0.19)ng/L,(0.43±0.23)ng/L in the control group(all P<0.05).There were significant differences in the IL-16,IL-18,IGF-1,IGFBP-3 levels among the children with nephritis grade Ⅳ,Ⅲ,Ⅱ,gradeⅠ:(154.22±26.82)ng/L,(279.5±10.28)ng/L,(1.31±0.26)ng/L,(1.47±0.36)ng/L;(117.27±8.20)ng/L,(210.45±10.92)ng/L,(0.98±0.12)ng/L,(0.87±0.24)ng/L;(92.14±6.54)ng/L,(160.46±8.49)ng/L,(0.84±0.17)ng/L,(0.69±0.23)ng/L;(67.36±4.38)ng/L,(105.34±6.33)ng/L,(0.39±0.02)ng/L,(0.48±0.05)ng/L;all P<0.05.The results of c

关 键 词：过敏性紫癜 肾炎 白细胞介素 胰岛素一号增长因子 胰岛素样生长因子结合蛋白-3 

分 类 号：R729[医药卫生—儿科]