一次性使用精密过滤输液器(TPE输液器)的药物相容性研究  

Study on drug compatibility of disposable precision filter infusion set

作　　者：李蕾 彭贤光 刘一怡 李风月 LI Lei;PENG Xianguang;LIU Yiyi;LI Fengyue(Beijing KJY Technology Co.,Ltd.,Beijing 100049,China;Teacher Education College,Capital Normal University,Beijing 100037,China)

机构地区：[1]北京康健源科技有限公司,北京100049 [2]首都师范大学教师教育学院,北京100037

出　　处：《药学研究》2019年第12期738-740,744,共4页Journal of Pharmaceutical Research

摘　　要：目的试验选择盐酸左氧氟沙星氯化钠注射液、注射用头孢曲松钠、硝酸甘油注射液、地西泮注射液等4种药液,考察热塑性弹性体(TPE)输液器与不同类型药物的相容性。方法模拟临床使用的条件,检测上述药液流经热塑性弹性体输液器前后性能指标的变化情况。结果热塑性弹性体输液器与盐酸左氧氟沙星氯化钠注射液和注射用头孢曲松钠的相容性良好;热塑性弹性体输液器对硝酸甘油和地西泮在接触初期有一定吸附,后期逐渐恢复至平衡。结论本试验为热塑性弹性体输液器的安全性提供依据。Objective To evaluate the compatibility of TPE infusion set with different types of drugs,four drugs including levofloxacin hydrochloride sodium chloride injection,ceftriaxone sodium for injection,nitroglycerin injection and diazepam injection were investigated in this study.Methods The changes of drug properties were determined before and after the solution flowing through TPE infusion set under simulating clinical condition.Results The results showed that TPE infusion set had good compatibility with Levofloxacin Hydrochloride and Ceftriaxone Sodium respectively.While,TPE infusion set adsorbed Nitroglycerin Injection and Diazepam at the initial stage,then rebalance at the final stage.Conclusion This study provided a basis for the safety evaluation of TPE infusion set.

关 键 词：热塑性弹性体(TPE) 药物相容 热塑性弹性体输液器 吸附 

分 类 号：R197.39[医药卫生—卫生事业管理]