慢性乙型肝炎及非酒精性脂肪性肝炎患者肝脏病理特征分析  

Analysis of pathological characteristics on chronic hepatitis B and nonalcoholic steatohepatitis

作　　者：朱永芬[1] 王进[2] 方家追 吕芳芳[1] ZHU Yong-fen;WANG Jin;FANG Jia-zhui(Department of Hepatology and infection,Shao Yifu Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou Zhejiang,310016,China;不详)

机构地区：[1]浙江大学医学院附属邵逸夫医院肝病感染科,浙江杭州310016 [2]浙江大学医学院附属邵逸夫医院病理科

出　　处：《中西医结合肝病杂志》2019年第6期505-506,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：浙江省自然科学基金(No:LY15H030009)

摘　　要：目的:分析研究非酒精性脂肪性肝炎及慢性乙型肝炎患者肝脏病理特征。方法:选取经过病理证实的非酒精性脂肪性肝炎30例患者和慢性乙型肝炎22例患者为研究对象,将二者病理分解为界面性肝炎、小叶内炎症、汇管区纤维化、窦周纤维化4个特征进行分析。结果:慢性乙型肝炎组患者2级以上界面性肝炎发生率明显高于非酒精性脂肪性肝炎组(100%vs 10%,P<0.001),2级以上汇管区纤维化发生率明显高于非酒精性脂肪性肝炎组(77.2%vs 16.7%,P<0.001)。两组患者小叶内炎症的发生率没有明显差异。结论:慢性乙型肝炎组患者2级以上界面性肝炎和2级以上汇管区纤维化发生率明显高于非酒精性脂肪性肝炎组患者。Objective:To analyze the pathological features of nonalcoholic steatohepatitis and chronic hepatitis B.Methods:The incidence of Interfacial hepatitis over grade 2 and periportal fibrosis over grade 2 in chronic hepatitis B were significantly higher than nonalcoholic steatohepatitis group(100% vs 10% and 77.2% vs 16.7%, both P<0.001). There was no significant difference in the incidence of lobular inflammation between the two groups. Results:The incidence of Interfacial hepatitis and periportal fibrosis over grade 2 in the chronic hepatitis B were higher than in non-alcoholic steatohepatitis.Conclusion:The incidence of Interfacial hepatitis and periportal fibrosis over grade 2 in the chronic hepatitis B were higher than in non-alcoholic steatohepatitis.

关 键 词：肝炎 乙型 慢性 非酒精性脂肪性肝炎 界面性肝炎 病理特征 

分 类 号：R512.62[医药卫生—内科学] R575[医药卫生—临床医学]