β-hCG、CA125联合孕酮检查对预测先兆流产结局的临床意义  

The clinical significance of β-hCG, CA125 and progesterone in predicting the outcome of threatened abortion

作　　者：吴惠子 吴惠珍[2] 吴贵华 钟凯凌 李海东 WU Hui-zi;WU Hui-zhen;WU Gui-hua(Department of Clinical Laboratory,Jieyang Industrial Transfer Industrial Park People’s Hospital,Jieyang 522000,China)

机构地区：[1]广东省揭阳产业转移工业园人民医院检验科,522000 [2]右江民族医学院附属医院,533000

出　　处：《中国实用医药》2020年第1期22-24,共3页China Practical Medicine

摘　　要：目的分析血清β-人绒毛膜促性腺激素(β-hCG)、糖类抗原125(CA125)及孕酮(P)联合检查对预测先兆流产结局的临床意义。方法150例先兆流产孕妇,根据结局不同分为妊娠组(继续妊娠,98例)和流产组(妊娠失败,52例);选取同期正常妊娠孕妇100例作为对照组。检测所有孕妇的β-hCG、CA125和孕酮水平,比较三组就诊时β-hCG、CA125、孕酮水平,就诊48 h后β-hCG、孕酮水平变化情况;分析β-hCG、CA125、孕酮对先兆流产结局的预测效能。结果就诊时,对照组β-hCG、孕酮水平均高于妊娠组及流产组,妊娠组高于流产组,差异具有统计学意义(P<0.05);对照组CA125水平(37.67±6.12)kU/L低于妊娠组的(49.89±8.12)kU/L、流产组的(78.29±10.21)kU/L,妊娠组明显低于流产组,差异均具有统计学意义(P<0.05)。就诊48 h后,妊娠组和对照组β-hCG增幅>50%、孕酮上升占比均高于流产组,β-hCG与孕酮均下降占比低于流产组,差异具有统计学意义(P<0.05)。流产组β-h CG、孕酮水平的95%可信区间的高限分别1542 mIU/ml、26.3 nmol/L,CA125的95%可信区间的低限为70.14 kU/L,三个指标联合检测预测先兆流产妊娠结局的特异度和准确度高于β-h CG、CA125、孕酮单一检测。结论β-h CG、CA125和孕酮联合监测对早期先兆流产结局的判断具有重要意义。Objective To analyze the clinical significance ofβ-human choionic gonadotophin(β-hCG),carbohydrate antigen 125(CA125)and progesterone(P)in predicting the outcome of threatened abortion.Methods A total of 150 pregnant women with threatened abortion were divided into pregnancy group(continuous pregnancy,98 cases)and abortion group(pregnancy failure,52 cases)by different outcomes,and 100 normal pregnant women in the same period were selected as the control group.The levels ofβ-hCG,CA125 and progesterone levels was detected in all pregnant women.The levels ofβ-hCG,CA125 and progesterone were compared between the three groups at the time of consultation,and the changes ofβ-hCG and progesterone levels after 48 h were analyzed.The predictive efficacy ofβ-hCG,CA125 and progesterone on the outcome of threatened abortion was analyzed.Results At the time of consultation,theβ-hCG and progesterone level in the control group was higher than those in pregnancy group and abortion group,and the pregnancy group was higher than abortion group.Their difference was statistically significant(P<0.05).The CA125 level(37.67±6.12)kU/L in the control group was lower than(49.89±8.12)kU/L in pregnancy group and(78.29±10.21)kU/L in abortion group.Their difference was statistically significant(all P<0.05).At 48 h after consultation,the proportion ofβ-hCG increase>50%and progesterone rising in pregnancy group and control group was higher than those in abortion group,and proportion ofβ-hCG and progesterone decline was lower than those in abortion group.Their difference was statistically significant(P<0.05).The high limit of 95%confidence interval ofβ-hCG and progesterone in abortion group was 1542 mIU/ml and 26.3 nmol/L respectively,and the low limit of 95%confidence interval of CA125 was 70.14 Ku/L.The specificity and accuracy of the combined detection of three indicators to predict the pregnancy outcome of threatened abortion are higher than the single detection ofβ-hCG,CA125,and progesterone.Conclusion The combined detection of�

关 键 词：Β-人绒毛膜促性腺激素 糖类抗原125 孕酮 先兆流产 

分 类 号：R714.21[医药卫生—妇产科学]