抑郁症临床治愈患者中央执行网络功能连接研究  

The functional connection of central executive network in patients with depression after clinical cure

作　　者：钟佳琪 王珍珍 韩洋 滕昌军 王慧 张宁[2] 马辉[2] Zhong Jiaqi;Wang Zhenzhen;Han Yang;Teng Changjun;Wang Hui;Zhang Ning;Ma Hui(School of Psychology,Nanjing Normal University,Nanjing 210097,China;Medical Psychology Department,Nanjing Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京师范大学心理学院,210097 [2]南京医科大学附属脑科医院医学心理科,210029

出　　处：《中华行为医学与脑科学杂志》2019年第12期1085-1090,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：江苏省重点研发计划(社会发展)项目(BE2015609);南京市医学科技发展重点项目(ZKX10022);南京医科大学科技发展基金(NMUB2018197)。

摘　　要：目的研究抑郁症患者达到临床治愈后其中央执行网络功能连接的变化情况。方法选取17名达到临床治愈标准的抑郁症患者(患者组)和22名健康对照(对照组)。分别对健康对照组和患者组进行基线rs-fMRI数据采集,6个月后对患者组被试进行再一次数据采集,比较两组中央执行网络功能连接变化。结果基线数据比较,患者组与对照组相比在左侧顶下小叶(MNI:x,y,z=-39,-69,33)及右侧脑岛(MNI:x,y,z=15,-45,30)存在高功能连接;患者组临床治愈6个月与基线期相比在部分左侧顶下小叶(MNI:x,y,z=-60,-48,21)及右侧背外侧前额叶(MNI:x,y,z=24,18,60)存在高功能连接,部分左侧顶下小叶(MNI:x,y,z=-51,-69,18)存在低功能连接;治愈6个月后患者组与健康对照组相比在右侧背外侧前额叶(MNI:x,y,z=45,51,-6)与右侧顶下小叶(MNI:x,y,z=42,-48,27)存在高功能连接。结论达到临床治愈标准后6个月,抑郁症患者中央执行网络异常的功能连接尚未恢复,相关异常并不稳定。Objective To study the changes in the functional connections of the central executive network in patients with depression after clinical cure.Methods Seventeen depression patients who met the clinical cure standard(patient group)and twenty-two healthy controls(control group)were selected.The baseline rs-fMRI data were collected from the healthy control group and the patient group respectively,and the rs-fMRI data in the patient group were collected again after 6 months.Compared the changes of central executive network function connection between the two groups.Results At baseline,there was a high functional connection in the left inferior parietal lobule(MNI:x,y,z=-39,-69,33)and right insula(MNI:x,y,z=15,-45,30)in the patient group compared with the control group.Compared with the baseline,there were high functional connections in part of the left inferior parietal lobe(MNI:x,y,z=-60,-48,21)and the right dorsolateral prefrontal lobe(MNI:x,y,z=24,18,60),and low functional connections in part of the left inferior parietal lobe(MNI:x,y,z=-51,-69,18)in patient group 6 months after clinical cure.Compared with the control group,there was a high functional connection in the right dorsolateral prefrontal lobe(MNI:x,y,z=45,51,-6)and the right inferior parietal lobe(MNI:x,y,z=42,-48,27)in patient group 6 months after clinical cure.Conclusion The functional connection of central executive network of depression patients has not been restored,and the related abnormality is not stable in six months after reaching the clinical cure standard.

关 键 词：中央执行网络 临床治愈 抑郁症 静息态功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]