KED-ICP-MS快速分析尿液中砷、镉、铊、铅  

Rapid Determination of Arsenic, Cadmium, Plumbum and Thallium in Human Urine by KED-ICP-MS

作　　者：杨丽婷 李菊[2] 王静[2,3] 郭怀兰 YANG Li-ting;LI Ju;WANG Jing;GUO Huai-lan(Biomedical Research Institute,Hubei University of Medicine,Shiyan,Hubei 442000,China;Center for Environment and Health in Water Source Area of South-to-North Water Diversion,Hubei University of Medicine,Shiyan,Hubei 442000,China;School of Public Health and Management,Hubei University of Medicine,Shiyan,Hubei 442000,China)

机构地区：[1]湖北医药学院生物医药研究院,湖北十堰442000 [2]湖北医药学院南水北调水源地环境与健康研究中心,湖北十堰442000 [3]湖北医药学院公共卫生与管理学院,湖北十堰442000

出　　处：《湖北医药学院学报》2019年第6期535-538,共4页Journal of Hubei University of Medicine

基　　金：国家自然科学基金项目(81372998);湖北医药学院硕士启动金(2018QDJZR28)

摘　　要：目的:运用电感耦合等离子体质谱(ICP-MS)技术建立快速、准确获取人体尿液中低浓度的砷(As)、镉(Cd)、铊(Tl)及铅(Pb)4种毒性元素含量的分析方法。方法:尿样经过硝酸过夜处理后稀释20倍,直接运用ICP-MS分析4种毒性元素,并观察工作曲线的判定系数、检测限,验证本方法的准确度与精密度。结果:4种毒性元素的检出限介于0.038~2.857 ng/L之间,各元素范围内线性相关系数(r)均≥0.999。各元素加标回收率在88%~108%之间,尿样质控L2均在参考范围内。结论:本方法具有快速、简便的优点,能够满足大批量尿样中4种毒性元素的快速、准确检测的要求。Objective To establish a rapid and accurate determination method of four toxic elements such as arsenic(As), cadmium(Cd), thallium(Tl) and plumbum(Pb) in human urine by inductively coupled plasma mass spectrometry(ICP-MS). Methods Urine samples were diluted 20 times after overnight treatment with nitric acid. Four kinds of toxic elements were directly analyzed by ICP-MS. The correlation coefficient and detection limit of the working curve were observed to verify the accuracy and precision of the method. Results The detection limits of the four toxic elements were between 0.038~2.857 ng/L, and the linear correlation coefficients(r) in each element range were ≥0.999. The recovery of each element was between 88%~108%, and the quality control L2 of urine sample is within the reference range. Conclusion The method has the advantages of rapid, and simple, and can meet the requirements of rapid and accurate detection of four toxic elements in a large number of urine samples.

关 键 词：电感耦合等离子体质谱 尿样 毒性元素 碰撞反应池 

分 类 号：R446.12[医药卫生—诊断学] O657.63[医药卫生—临床医学]