基于磁共振扩散峰度成像直肠癌生物学特征研究  

Study on biological characteristics of rectal cancer based on magnetic resonance diffusion kurtosis imaging

作　　者：王莉莉[1] 李生虎[2] 黄刚[1] 许华新[1] 崔雅琼 马小梅[1] 崔兰兰[1] WANG Lili;LI Shenghu;HUANG Gang;XU Huaxin;CUI Yaqiong;MA Xiaomei;CUI Lanlan(Department of radiology,Gansu Provincial Hospital,Lanzhou 730000,China;Department of radiology,Wuxi Hospital of traditional Chinese medicine,Jiangsu Province,Wuxi 214000,China)

机构地区：[1]甘肃省人民医院放射科,兰州730000 [2]江苏省无锡市中医医院放射科,无锡214000

出　　处：《磁共振成像》2020年第1期35-39,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：甘肃省人民医院院内科研基金(编号：16GSSY1-7);甘肃省兰州市科技发展指导性项目基金(编号：2015-ZD-21)~~

摘　　要：目的基于磁共振扩散峰度成像,探讨直肠癌分期、分化程度、组织学类型、p53及HER-2之间相互关系。材料与方法纳入2017年至2019年直肠癌患者63例回顾性分析,所有患者术前一周内进行MRI检查,检查序列包含DKI成像,所得数据导入专用软件,获取DKI参数及术后病理生物学特征资料进行统计分析。用单因素方差分析比较DKI参数在组织学类型、肿瘤分期、分化程度、p53及HER-2阴性或阳性间的关系。用Kruskal-Wallis H检验分析直肠癌生物学特征对DKI参数有无影响。Spearman等级相关分析生物学特征与DKI参数之间相互关系。ROC曲线分析DKI参数对p53及HER-2阴性或阳性的诊断效能,P<0.05为有统计学意义。结果(1)组织学类型、肿瘤分期、分化程度对DKI参数有不同程度影响。(2)MK与直肠癌分期、分化程度有统计学意义,与分期呈正相关,与分化程度呈负相关(r=0.285,-0.296)。MD与组织学类型呈负相关(r=-0.375)。FA与p53、分化程度呈正相关(r=0.254,0.256),直肠分期呈负相关(r=-0.315,-0.399)。(3)FA预测p53曲线下面积为0.651,说明诊断效能中等,95%置信区间(0.502,0.800)。结论磁共振扩散峰度成像与直肠癌生物学特征之间存在一定的相互关系,磁共振扩散峰度成像对直肠癌预后及治疗方案选择具有指导意义。Objective:Based on magnetic resonance diffusion kurtosis imaging,the relationship between staging,differentiation,histological type,p53 and HER-2 was investigated.Materials and Methods:A retrospective analysis of 63 cases of rectal cancer patients from 2017 to 2019,MRI examination within one week before surgery,the examination sequence contain DKI imaging and the data obtained were imported into special software for analysis.The DKI parameter and postoperative pathological biological characteristics were obtained for statistical analysis.One-way ANOVA was used to compare the relationship between DKI parameters in histologic type,tumor stage,degree of differentiation,p53 and HER-2 group.The KruskalWallis H test analyzes whether the biological characteristics of rectal cancer have an effect on DKI parameter.Spearman correlation coefficient analysis biological relationship and DKI parameter.The ROC curve was used to analyze the diagnostic efficacy of DKI parameter for p53 and HER-2 negative or positive,P<0.05 was considered statistically significant.Results:(1)The histological type,tumor stage and degree of differentiation have different effects on DKI parameter.(2)MK and rectal cancer stage and differentiation were statistically significant,positively correlated with stage,and negatively correlated with degree of differentiation(r=0.285,-0.296).MD was negatively correlated with histological type(r=-0.375).There was a positive correlation between FA and p53,degree of differentiation(r=0.254,0.256),and a negative correlation with rectal stage(r=-0.315,-0.399).(3)The area under the FA prediction p53 performance curve was 0.651,indicating a moderate diagnostic efficiency with a 95%confidence interval(0.502,0.800).Conclusions:Significant correlations were found between the magnetic resonance diffusion kurtosis imaging and the biological characteristics of rectal cancer,which maybe guide for the prognosis and treatment options of rectal cancer.

关 键 词：直肠肿瘤 磁共振成像 免疫组织化学 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.37[医药卫生—诊断学]