解读“2019年ACR及EULAR IgG4相关性疾病分类标准”  

Interpreting of “The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease”

作　　者：刘航[1,2,3] 杨娉婷 肖卫国[1] 张文[4] LIU Hang;YANG Ping-ting;XIAO Wei-guo;ZHANG Wen(Department of Rheumatology and Immunology,First Hospital of China Medical University,Shenyang 110001,China;Division of Rheumatology,Allergy and Immunology,Massachusetts General Hospital,Boston,MA02114,USA;Ragon Institute of MGH,MIT and Harvard,Cambridge,MA 02139,USA;Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,National Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID),Key Laboratory of Ministry of Health,Beijing 100730,China)

机构地区：[1]中国医科大学附属第一医院风湿免疫科,沈阳110001 [2]美国麻省总医院风湿免疫科,美国马萨诸塞州波士顿02114 [3]美国麻省总医院,麻省理工学院和哈佛大学拉根研究所,美国马萨诸塞州剑桥02139 [4]中国医学科学院北京协和医学院北京协和医院风湿免疫科国家皮肤与免疫疾病临床医学研究中心卫生部重点实验室,北京100730

出　　处：《中华临床免疫和变态反应杂志》2019年第6期447-453,共7页Chinese Journal of Allergy & Clinical Immunology

基　　金：中国医学科学院医学与健康科技创新工程项目(2017-I2M-3-001);国家重点研发计划(2016YFC0901500);国家自然科学基金(81771757,81571587)~~

摘　　要：IgG4相关性疾病(IgG4-related disease,IgG4-RD)是一种免疫介导的,可累及几乎全身各个器官,并导致受累器官肿瘤样病变、组织破坏、功能障碍,甚至衰竭的炎症伴纤维化疾病。特异性和敏感性高的分类标准有助于临床和流行病学研究的一致性。2019年12月Arthritis&Rheumatology杂志发表了"2019年ACR及EULAR IgG4相关性疾病分类标准",是迄今为止全球多个国家参与的关于IgG4-RD首个国际分类标准,对IgG4-RD具有里程碑意义。本文介绍并解读该分类标准的制定方法、内容及其对未来临床、流行病学和基础研究的重要贡献。IgG4-related disease(IgG4-RD) is an immune-mediated fibrotic disease that can occur at nearly any anatomic site and lead to tumefactive, tissue-destructive lesions, organ dysfunction or even failure. High specificity and sensitivity classification criteria will facilitate consistency of clinical and epidemiological studies. The American College of Rheumatology and European League Against Rheumatism(ACR/EULAR) have just published a classification criteria for IgG4-RD in December, 2019 in Arthritis & Rheumatology. As the first international classification criteria investigated by worldwide specialists, IgG4-RD classification criteria represent a significant milestone in the IgG4-RD. This work was undertaken to introduce the development and validation of an international set of classification criteria for IgG4-RD and to interpret this contribution to future clinical, epidemiologic, and basic science investigations.

关 键 词：IGG4相关性疾病 分类标准 

分 类 号：R593.2[医药卫生—内科学]