细胞外囊泡参与调控外源因素诱导的肝毒性损伤的研究进展  

Research progresses of extracellular vesicles in regulating hepatotoxic damage induced by exogenous factors

作　　者：江珊 吕鹏 林忠宁[1] 刘刚[1] JIANG Shan;L Peng;LIN Zhongning;LIU Gang(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学公共卫生学院分子疫苗学和分子诊断学国家重点实验室

出　　处：《厦门大学学报（自然科学版）》2020年第1期10-18,共9页Journal of Xiamen University：Natural Science

基　　金：国家重点研发计划项目(2017YFA0205201);国家自然科学基金(81422023,51273165,U1705281,U1505221);教育部新世纪优秀人才支持计划项目(ncet-13-0502)

摘　　要：肝脏是机体代谢外源因素的主要功能性器官,其具有独特的血窦结构和丰富的细胞组成,而细胞的功能改变是造成肝毒性损伤的主要原因.细胞外囊泡(EVs)是由脂质双分子层所形成的纳米级球形囊泡,几乎源自各类细胞,用于负载特定的内容物,并可作为载体介导相邻或远处细胞间的信息交流.该文综述了外源因素暴露下,EVs介导肝毒性损伤进程中的细胞间通信,并探讨靶向干预EVs的具体途径,为预防和控制肝毒性损伤提供指导与参考.Liver is the main metabolic organ with the unique sinusoid structure and abundant cell types,which plays an important role in metabolizing exogenous factors.Importantly,the functional impairment of hepatocytes is the leading cause of hepatotoxic damage.Extracellular vesicles(EVs),with nano size and lipid bilayer membrane,are produced by almost all types of cells.EVs serve as potential carriers by loading and transporting specific molecules,mediating cellular cross-talks between nearby or distant cells.In this review,we mainly discuss the intercellular communication and specific approaches of targeted interventions in the process of EVs-mediated hepatotoxic damage under exogenous factors exposure,which provides further guidance and reference for preventing and controling hepatotoxic damage.

关 键 词：细胞外囊泡 细胞间通信 肝毒性损伤 外源因素 靶向干预 

分 类 号：R543[医药卫生—心血管疾病]