壳聚糖交联智能型水凝胶的制备与降解性能  

Synthesis and Degradation Characterization of Intelligent Hydrogels Cross-Linked by N-Maleyl Chitosan

作　　者：刘夕升 隋美玉 赵聪 于跃芹[1] Xisheng Liu;Meiyu Sui;Cong Zhao;Yueqin Yu(Key Laboratory of Eco-Chemical Engineering,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]青岛科技大学化学与分子工程学院生态化工教育部重点实验室培育基地

出　　处：《高分子材料科学与工程》2019年第12期138-142,共5页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(20876081);山东省自然科学基金资助项目(ZR2012BM015)

摘　　要：将天然产物壳聚糖改性后引入聚N-异丙基丙烯酰胺(PNIPAAm)温敏性水凝胶体系,研究了N-马来酰化壳聚糖(N-MACH)对水凝胶的温敏性、溶胀性、压缩强度和降解性的影响。结果发现,当N-MACH的含量为30%时,合成的水凝胶不仅具有较好的温敏性和溶胀性能,且其压缩强度比只有BIS交联的PNIPAAm水凝胶提高了311.2%。在40℃、pH 5.0条件下,N-MACH引入量为30%水凝胶在纤维素酶溶液(8 U/mL)中的降解率可达到60.8%,进一步为壳聚糖交联水凝胶在生物领域的应用提供了良好条件。The natural product chitosan modified with maleic anhydride was introduced into the thermoresponsive hydrogels,poly N-isopropyl acrylamide(PNIPAAm).Effect of N-malay acylation chitosan(N-MACH)on the thermoresponsive,swelling,compressive strength,and degradation of the hydrogels was investigated.The results suggest that when the content of N-MACH is 30%,the synthesized hydrogels not only have better temperature sensitivity and swelling performance,but also have a compression strength 311.2%higher than that of PNIPAAm hydrogels only crosslinked with BIS.In enzymatic degradation,the mass loss of the hydrogel with 30%N-MACH could be added up to 60.8%in the solution of cellulase(8 U/mL)at 40℃and pH 5.0,which furtherly provide the foundation for the application of chitosan crosslinked hydrogels in the biological field.

关 键 词：壳聚糖 聚N-异丙基丙烯酰胺水凝胶 温敏性 压缩强度 降解性 

分 类 号：TQ326.4[化学工程—合成树脂塑料工业]