树突状细胞在慢性乙型肝炎发病机制中的研究进展  

Advances in the study of dendritic cells in the pathogenesis of chronic hepatitis B

作　　者：朱其荣[1] 陈芳[1] 喻雪琴 陈星[1] 戢敏 梅怡晗 杨旺春[3] ZHU Qi-rong;CHEN Fang;YU Xue-qin;CHEN Xing;JI Min;MEI Yi-han;YANG Wang-chun(Department of Infectious Disease,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000;Capital Medical University,Beijing 100054;Department of Infectious Disease,Yuechi People's Hospital,Guang’an 638350,Sichuan,China)

机构地区：[1]川北医学院附属医院感染科,四川南充637000 [2]首都医科大学,北京610041 [3]岳池县人民医院感染科,四川广安638350

出　　处：《川北医学院学报》2019年第6期828-831,共4页Journal of North Sichuan Medical College

基　　金：四川省卫生厅课题(130343)

摘　　要：乙型肝炎病毒(HBV)是一种嗜肝DNA病毒,以慢性感染多见,我国约有9300多万的HBV感染者,慢性乙型肝炎(CHB)患者约3000多万人。HBV慢性感染及CHB的形成与机体免疫状况关系密切,作为目前最为强大专职抗原呈递功能的树突状细胞(DC)是诱导和开启机体特异性免疫应答与调节免疫平衡的关键环节。CHB的发病机制尚不完全明确,但肝细胞的损伤与机体免疫状态及免疫应答关系紧密,免疫应答可清除HBV,但也亦导致肝细胞损伤或HBV变异。目前研究结果显示,在HBV感染中DC发育不成熟与功能障碍是导致HBV感染慢性化与CHB形成的主要原因之一。Hepatitis B virus(HBV)is a common hepatotropic DNA virus.Chronic infection is common.There are more than 93 million HBV infected people and more than 30 million CHB patients in China.Chronic HBV infection and chronic hepattitis B(CHB)are closely related to the immune status of the body.As the Dendirtie CellS(DC)with the most powerful professional antigen presenting function,they are the key link to induce and open the specific immune response of the body and regulate the immune balance.The pathogenesis of chronic hepatitis B is not completely clear,but the damage of liver cells is closely related to the immune status and immune response of the body,which can clear HBV,but also lead to liver cell damage or HBV variation.Current research results show that immature DC and dysfunction in HBV infection are one of the main causes of chronic HBV infection and chronic hepatitis B.

关 键 词：树突状细胞 慢性乙型肝炎 抗原提呈细胞 

分 类 号：R512.6[医药卫生—内科学]