中老年颈动脉狭窄患者与严重龋病的相关性研究  

Correlation study between severe dental caries and carotid artery stenosis in middle-aged and elderly patients

作　　者：王颖[1] 韩同磊 谢永富 吴雅妮 朱江 孙羽东 魏小龙 赵志青 WANG Ying;HAN Tong-lei;XIE Yong-fu;WU Ya-ni;ZHU Jiang;SUN Yu-dong;WEI Xiao-long;ZHAO Zhi-qing(Department of Vascular Surgery,The First Hospital of Qiqihar,Qiqihar 161005,China;Department of Vascular Surgery,Changhai Hospital Affiliated to Naval Medical University,Shanghai 200433,China)

机构地区：[1]齐齐哈尔市第一医院血管外科,黑龙江齐齐哈尔161000 [2]海军军医大学附属长海医院血管外科,上海200433

出　　处：《中国血管外科杂志（电子版）》2019年第4期270-273,277,共5页Chinese Journal of Vascular Surgery(Electronic Version)

摘　　要：目的评估中老年颈动脉狭窄患者与龋病是否存在相关性。方法选取2017年3月至2018年9月收治的中老年颈动脉狭窄患者167例。根据龋病损伤程度分为轻度、中度、重度龋病组和无龋病组,对比分析各组的一般临床资料以及炎症指标、狭窄程度以及动脉内膜厚度上有无差异。结果中重度龋病组,即存在牙髓龋和慢性根尖周炎的颈动脉狭窄患者的白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hsCRP)均显著高于轻度龋病组和无龋病组(P<0.05)。无龋病组的颈动脉狭窄程度以轻度为主(P<0.001),颈动脉内中膜厚度与龋病程度之间无相关性(P=0.319)。相关性分析显示,在龋病患者中颈动脉狭窄程度评分与IL-6、TNF-α、hsCRP均为正相关(r分别为0.790、0.818、0.791,P<0.001)。结论伴随严重龋病的颈动脉狭窄患者中重度狭窄的比例较高,但龋病程度与颈动脉内中膜厚度之间无相关性。Objective To assess the correlation between dental caries and carotid stenosis in middle-aged and elderly patients.Methods A total of 167 patients with middle-aged and elderly carotid stenosis from March 2017 to September 2018 were enrolled.According to the degree of caries damage,the patients were divided into mild,moderate,severe caries and no-caries groups.The general clinical data of each group as well as the inflammatory index,stenosis degree and arterial intimal-medial thickness(IMT)were compared.Results IL-6,TNF-αand hsCRP were significantly higher in the moderately severe caries group than in the mild caries and no-caries groups(P<0.05).The degree of carotid stenosis was mild in the non-sick group(P<0.001),and there was no correlation between carotid IMT and caries degree(P=0.319).Correlation analysis showed that carotid stenosis scores were positively correlated with IL-6,TNF-αand hsCRP in patients with dental caries(r=0.790,0.818 and 0.791,respectively,P<0.001).Conclusion There is a higher proportion of severe stenosis in patients with severe caries,but no correlation between caries degree and IMT.

关 键 词：龋病 颈动脉狭窄 相关性研究 

分 类 号：R543.4[医药卫生—心血管疾病] R781.1[医药卫生—内科学]