病毒感染在皮肤鳞状细胞癌中的研究进展  

Research Progress of Viral Infection in Cutaneous Squamous Cell Carcinoma

作　　者：唐洪波 梁俊琴[2] TANG Hongbo;LIANG Junqin(Graduate School,Xinjiang Medical University,Urumqi 830002,China;Department of Dermatology,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830002,China)

机构地区：[1]新疆医科大学研究生学院,乌鲁木齐830002 [2]新疆维吾尔自治区人民医院皮肤科,乌鲁木齐830002

出　　处：《医学综述》2020年第1期18-23,共6页Medical Recapitulate

基　　金：国家自然科学基金(81760494)

摘　　要：皮肤鳞状细胞癌(CSCC)属于非黑色素瘤皮肤癌,是源于上皮组织中角质形成细胞的恶性肿瘤,作为人类第二常见皮肤癌,其转移率和病死率较高。CSCC通常发生在暴露区域(如头部、颈部和四肢),发病率随年龄增长而增加。高风险CSCC患者复发和死亡的风险更高。目前除紫外线外,病毒感染引起的CSCC也越来越受关注,人乳头瘤病毒、人疱疹病毒8型、Merkel细胞多瘤病毒等与CSCC有直接的关系。未来进一步了解病毒感染的作用机制对于CSCC的预防、治疗具有重要意义。Cutaneous squamous cell carcinoma(CSCC)belongs to non-melanoma skin cancer,which is a malignant tumor derived from keratinocytes in epithelial tissues.As the second most common skin cancer in humans,it has high metastasis rate and mortality.CSCC usually occurs in exposed areas(such as the head,neck,and extremities),and the incidence increases with age.Patients at high risk CSCC have a higher risk of recurrence and death.At present,in addition to ultraviolet light,CSCC caused by viral infection is also receiving more and more attention.Human papilloma virus,human herpesvirus 8 and Merkel cell polyomavirus have direct relationships with CSCC.In the future,further understanding of the mechanisms is of great significance for the prevention and treatment of CSCC.

关 键 词：皮肤鳞状细胞癌 人乳头瘤病毒 人疱疹病毒8型 Merkel细胞多瘤病毒 

分 类 号：R75[医药卫生—皮肤病学与性病学]