TLRs介导的炎症信号通路与变应性鼻炎发病机制研究进展  

Research Progress in TLRs-Mediated Inflammatory Signaling Pathways and Pathogenesis of Allergic Rhinitis

作　　者：古丽白热木·玉素因 毛艳 刘燕 贺金华 顾政一 穆合塔尔·阿卜杜热合木 GULIBAIREMU·Yusuyin;MAO Yan;LIU Yan;HE Jinhua;GU Zhengyi;MUHETAER·Abudurehemu(College of Pharmacy,Xinjiang Medical Univercity,Urumqi 830011,China;Institute of Materia Medica Xinjiang Uyghur Autonomous Region,Urumqi 830004,China;Department of Spinal Surgery,Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830004,China)

机构地区：[1]新疆医科大学药学院,乌鲁木齐830011 [2]新疆维吾尔自治区药物研究所,乌鲁木齐830004 [3]新疆医科大学第六附属医院脊柱外科,乌鲁木齐830004

出　　处：《医学综述》2020年第1期50-53,58,共5页Medical Recapitulate

摘　　要：变应性鼻炎(AR)已成为全球性健康问题,人们对于根治该病的需求越来越迫切。目前关于AR炎症发病机制相关信号通路的研究越来越多,其中Toll样受体(TLRs)介导的信号通路与AR相关的研究最多,主要包括TLRs/核因子κB通路、TLRs/髓样分化因子88通路、TLRs/促分裂原活化的蛋白激酶通路、白细胞介素-33/受体瘤变抑制因子2通路、胸腺基质淋巴细胞生成素/OX40配体通路以及高迁移率族蛋白B1/TLR4通路等。TLRs作为与炎症相关的最重要通路之一,也参与其他疾病的发生发展,因此针对TLRs介导的信号通路治疗AR还有待深入研究。Allergic rhinitis(AR)has become a global health problem,and the need for its eradication is becoming more and more urgent.At present,there are more and more studies on the signaling pathways related to the pathogenesis of AR inflammation,among which Toll-like receptors(TLRs)mediated signaling pathways are the most widely studied,mainly including TLRs/nuclear factor-κB pathway,TLRs/myeloid differentiation factor 88 pathway,TLRs/mitogen activated protein kinases pathway,interleukin-33/suppression of tumorigenicity 2 pathway,thymic stromal lymphopoietin/OX40 ligand pathway and high mobility group box protein B1/TLR4 pathway etc.TLRs-mediated signaling pathways as the important pathway of the body,also participate in the occurrence and development of other diseases,so the treatment of AR with TLRs-mediated signal pathway needs to be further studied.

关 键 词：变应性鼻炎 TOLL样受体 信号通路 核因子ΚB 髓样分化因子88 促分裂原活化的蛋白激酶 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]