肿瘤微环境调控能量代谢的机制及分子影像在该领域的研究进展  

Energy Metabolism Regulation Mechanism of Tumor Microenvironment and Advances in Associated Molecular Imaging Research

作　　者：张国建[1] 白智刚[2] 王文睿[1] 王雪梅[1] 鲁海文[2] ZHANG Guojian;BAI Zhigang;WANG Wenrui;WANG Xuemei;LU Haiwen(Department of Nuclear Medicinehe Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Imaging Teaching and Research Office,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院核医学科,呼和浩特010050 [2]内蒙古医科大学附属医院影像教研室,呼和浩特010050

出　　处：《医学综述》2020年第1期59-62,70,共5页Medical Recapitulate

基　　金：国家自然科学基金(81960319);内蒙古自然科学基金(2017MS0825,2018MS08108);内蒙古自治区科技计划项目(kjt15sf01);内蒙古自治区卫生计生科研计划项目(201701077)

摘　　要：目前肺癌的各种治疗方法大多集中于肿瘤细胞本身,对于肿瘤生存的微环境及肿瘤能量代谢关注较少。肿瘤能量代谢对肺癌的发生、发展、侵袭及转移具有极其重要的作用,而乏氧微环境可能是驱动能量代谢的关键因素,但作用机制尚未完全阐明。针对肿瘤微环境与能量代谢的关系及机制进行探讨,能够指导临床从能量代谢的角度寻求肿瘤治疗策略,为肿瘤治疗提供有效靶点。而利用正电子发射计算机断层显像/CT、磁共振成像等分子影像学检查方法对肿瘤能量代谢进行活体水平评估,能为临床提供一种无创的检测手段。Now,most of the treatment methods for lung cancer focus on the tumor cells themselves,and less attention is paid to the tumor microenvironment and tumor energy metabolism.Tumor energy metabolism plays an important role in the occurrence,development,invasion and metastasis of lung cancer.Hypoxic microenvironment may be a key factor driving energy metabolism,but the action mechanism is not fully elucidated.The relationship between tumor microenvironment and energy metabolism and associated mechanism can guide the clinical search for tumor treatment strategies from the perspective of energy metabolism,and provide an effective target for the treatment.Assessment of living tumor energy metabolism using molecular imaging methods such as positron emission tomography/CT and magnetic resonance imaging can provide a non-invasive detection method for the clinic.

关 键 词：肿瘤 分子影像 肿瘤微环境 能量代谢 

分 类 号：R445.5[医药卫生—影像医学与核医学]