电子顺磁共振技术在生物样品辐射剂量重建中的应用研究进展  

Progress on application of electron paramagnetic resonance technology in radiation dose reconstruction of biological samples

作　　者：毕帆 胡海生[1] 石慧烽[1] 冯坤 樊文慧 涂文勇[1] BI Fan;HU Haisheng;SHI Huifeng;FENG Kun;FAN Wenhui;TU Wenyong(Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科

出　　处：《中国医学物理学杂志》2020年第1期29-32,共4页Chinese Journal of Medical Physics

基　　金：上海交通大学医学院技术转移项目(ZT201807)

摘　　要：电子顺磁共振技术可用于检测样品中的顺磁分子,可在较短时间内完成辐射剂量的重建,对于大范围辐射事故人群的剂量重建、分类诊治和医用X线人员辐射流行病学研究具有重要的现实意义。该文首先介绍了电子顺磁共振技术的基本原理和应用现状,该技术可直接检测物质中的顺磁分子,可在较短时间内提供吸收剂量的评估结果;然后分别从牙齿、指甲和其他生物样品的电子顺磁共振辐射剂量重建的应用现状与进展展开了综述,上述样品在剂量重建中均有优劣势,但在剂量重建的灵敏度和准确性方面需进一步研究,该综述以期为电子顺磁共振技术在生物样品剂量重建的相关研究提供新思路,为电子顺磁共振技术的进一步推广应用奠定基础。Electron paramagnetic resonance(EPR)technology which can be used to detect paramagnetic molecules in samples and to reconstruct radiation dose in a relatively short time has important practical significance for the dose reconstruction,diagnosis and treatment of large-scale radiation accidents and radiation epidemiology research by medical X-ray personnel.The basic principle and application status of EPR are firstly introduced.EPR can be used to directly detect paramagnetic molecules in substances and provide the evaluation results of absorbed doses in a short period of time.The application status and progress of dose reconstruction of EPR in teeth,nails and other biological samples are also reviewed.The above samples have their advantages and disadvantages in dose reconstruction,but the sensitivity and accuracy of dose reconstruction need to be further researched.This review aims to provide new ideas for the research of EPR technology in dose reconstruction of biological samples,thereby laying a foundation for the further promotion and application of EPR technology.

关 键 词：电子顺磁共振技术 生物样品 剂量重建 综述 

分 类 号：R318[医药卫生—生物医学工程] R818[医药卫生—基础医学]