红细胞分布宽度和血小板分布宽度的变化与急性心肌梗死疗效的关系  

Effects of acute myocardial infarction on the changes of erythrocyte distribution width and platelet distribution width

作　　者：程小兵[1] 陈燕[1] 罗娟娟[2] 杨玉雯 单其俊[4] CHENG Xiao-bing;CHEN Yan;LUO Juan-juan;YANG Yu-wen;SHAN Qi-jun(Department of Cardiovascular,Hefei Third People's Hospital,Anhui Medical University,Hefei 230022,Anhui,China;Department of Physiology,Gannan Medical College,Ganzhou 341000,Jiangxi,China;Department of Cardiovascular,the First Affiliated Hospital of Wannan Medical College,Wuhu 241002,Anhui,China;Department of Cardiovascular,the People's Hospital of Jiangsu Province,Nanjing 210029,Jiangsu,China)

机构地区：[1]安徽医科大学合肥第三临床学院(合肥市第三人民医院)心血管内科,合肥230022 [2]赣南医学院生理教研室,赣州341000 [3]皖南医学院第一附属医院心血管内科,芜湖241002 [4]南京医科大学第一附属医院心血管内科,南京210029

出　　处：《东南国防医药》2020年第1期33-37,共5页Military Medical Journal of Southeast China

基　　金：合肥市第三人民医院课题[院科合同2017(5)号]

摘　　要：目的探讨红细胞分布宽度(RDW)和血小板分布宽度(PDW)的变化在急性心肌梗死(AMI)治疗效果中的作用。方法选取2014年10月至2018年9月合肥市第三人民医院收治的110例急性心肌梗患者,根据治疗效果分为有效组和无效组。检测治疗前后的RDW和PDW,并计算红细胞分布宽度变化值(RDW-C)、血小板分度宽度变化值(PDW-C),以及红细胞分布宽度变化率(RDW-Cr)、血小板分布宽度变化率(PDW-Cr)。结果有效组较无效组的RDW、PDW变化值(-1.01±3.25 vs 1.62±2.12,-1.10±4.5 vs 0.25±1.2)及变化率(-2.15±6.2 vs 3.10±6.8,-6.3±9.3 vs 1.45±7.1)显著提高(P<0.01)。多因素Logistic回归分析显示RDW-C(OR=1.012,95%CI:1.015~1.121)、PDW-C(OR=1.011,95%CI:1.019~1.082)是疗效的独立预测因素(P<0.01)。ROC曲线分析显示,RDW和PDW的变化值及变化率在评价治疗效果方面差异均有统计学意义(P<0.05)。结论RDW与PDW治疗前后变化值及变化率可用于急性心肌梗死治疗效果的评价。Objective To investigate the role of erythrocyte distribution width(RDW)and platelet distribution width(PDW)in the treatment of acute myocardial infarction(AMI).Methods 110 cases of acute myocardial infarction in Hefei Third People's Hospital from October 2014 to September 2018 were selected and divided into effective group and ineffective group according to treatment effect.RDW and PDW were measured before and after treatment.The change values and rates of RDW and PDW were cal⁃culated[change values of erythrocyte distribution width(RDW-C),change values of platelet index width(PDW-C),change rates of erythrocyte distribution width(RDW-Cr),change rates of platelet distribution width(PDW-Cr)].Results The changes of RDW in the effective group(-1.01±3.25 vs 1.62±2.12)and PDW in the effective group(-1.10±4.5 vs 0.25±1.2),RDW rates(-2.15±6.2 vs 3.10±6.8)and PDW rates(-6.3±9.3 vs 1.45±7.1)were statistically significant(P<0.01).Multivariate logistic regression analysis found that RDW-C(OR=1.012,95%CI:1.015-1.121)and PDW-C(OR=1.011,95%CI:1.019-1.082)were indepen⁃dent predictors of efficacy(P<0.01).ROC curve analysis showed that the changes and rates of RDW and PDW were significantly different in evaluating the therapeutic effect(P<0.05). Conclusion the changes of RDW and PDW before and after treat⁃ment can be used to evaluate the therapeutic effect of acute myocardial infarction.

关 键 词：血小板分布宽度 红细胞分布宽度 心肌梗死 疗效 

分 类 号：R541.4[医药卫生—心血管疾病]