10%硫软膏的质量控制  

Quality Control of 10% Sulfur Ointment

作　　者：乔晓枝 买佳琪 季小青 杨璐[1] 史行 李云兰[1,2] QIAO Xiao-zhi;MAI Jia-qi;JI Xiao-qing;YANG-Lu;SHI Hang;LI Yun-lan(Shanxi Medical University,Taiyuan 030001,China;Shanxi University of Chinese Medical,Jinzhong,030619,China)

机构地区：[1]山西医科大学,山西太原030001 [2]山西中医药大学,山西晋中030619

出　　处：《中国医药指南》2019年第36期1-1,3,共2页Guide of China Medicine

基　　金：国家重大专项临床前研究品种“治疗糖尿病肾病国家一类新药海洋多酚LF1研发”(No.2017ZX09101003-001-017);山西省高校中青年拔尖创新人才(2015年);晋药综合开发利用协同创新中心项目“白花蛇舌草黄酮类抗癌保肝医院制剂研发”(2017-JYXT-18)

摘　　要：目的建立10%硫软膏的有效质量控制方法。方法使用碘量法测定制剂中的硫含量。结果碘量法用于测定15.0~75.0 mg的硫含量时线性良好(r^2=0.9999)。平均回收率为100.5%,RSD为1.3%(n=9)。结论本实验方法专属性强、重复性好、精密度高,能准确测量出10%硫软膏中有效成分含量并用于质量控制。Objective To establish an effective quality control method for 10% sulfur ointment. Methods The sulfur in sulfur ointment was measured by iodometry. Results The iodometry showed good linear response(r2=0.9999) in the range of 15.0~75.0 mg sulfur. The average recovery was 100.5%(RSD=1.3%, n=9). Conclusion The methods were specific, reproducible and highly precise, which could be applied to accurately measure the sulfur in 10% sulfur ointment and achieve the quality control.

关 键 词：硫软膏 质量控制 碘量法 

分 类 号：R282.710.2[医药卫生—中药学]