可见光促进下N-芳基丙烯酰胺甲基化合成3-甲基-3-乙基氧化吲哚  

Visible light-induced methylation of N-arylacrylamides to synthesize 3-ethyl-3-methyl oxindoles

作　　者：孙焕 蒋玥 杨莹莎 李云云 路明坤 刘吉开[1,2] SUN Huan;JIANG Yue;YANG Yingsha;LI Yunyun;LU Mingkun;LIU Jikai(School of Pharmaceutical Sciences,South⁃Central University for Nationalities,Wuhan 430074,China;National Demonstration Center for Experimental Ethnopharmacology Education,South⁃Central University for Nationalities,Wuhan 430074,China)

机构地区：[1]中南民族大学药学院,武汉430074 [2]中南民族大学民族药学国家级实验教学示范中心,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2020年第1期12-17,共6页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(81803395);湖北省自然科学基金资助项目(2018CFB222)

摘　　要：以过氧化苯甲酸叔丁酯为氧化剂,在可见光促进下通过N-芳基取代的丙烯酰胺类化合物的串联自由基加成/环化反应,实现了3-甲基-3-乙基氧化吲哚类化合物的合成.该反应具有反应条件温和、底物普适性较广等优势.Visible light-induced free-radical cascade methylation/cyclization of N-arylacrylamides was demonstrated by using tert-butyl peroxybenzoate as the oxidant, which provided a convenient access to 3-ethyl-3-methyl oxindoles. The reaction has the advantages of mild reaction conditions and wide substrate universality.

关 键 词：氧化吲哚 可见光促进 甲基化 

分 类 号：O621.3[理学—有机化学]