乳糖酶治疗婴儿生理性腹泻的效果  

Therapeutic effects of lactase in infant physiological diarrhea

作　　者：于果[1] 白玫[1] 张宏文[1] Yu Guo;Bai Mei;Zhang Hongwen(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院儿科

出　　处：《中华临床医师杂志（电子版）》2019年第5期363-366,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的观察乳糖酶对婴儿生理性腹泻的治疗效果。方法选择于我院门诊2017年1月至2018年12月期间就诊的生理性腹泻的婴儿,将同意应用乳糖酶治疗的73例作为观察组,不同意应用乳糖酶治疗的30例作为对照组。观察组给予乳糖酶治疗,对照组仅给予蒙脱石粉散和(或)肠道益生菌对症治疗,2组均随访超过3个月。分析乳糖酶对于生理性腹泻的治疗效果。同时采用生活质量综合评定问卷(GQOLI-74)分别评估患儿同一位家长病初和治疗1个月时心理状态的变化。结果观察组73例患儿中,显效65例(89.04%),有效8例(10.96%),无效0例(0),总有效率为100.00%。对照组30例患儿中,显效14例(46.67%),有效4例(13.33%),无效12例(40.00%),总有效率为60.00%。观察组总有效率明显高于对照组,差异具有统计学意义(P <0.05)。此外,与对照组比较,观察组的就诊次数、化验大便次数、腹泻相关并发症明显较少,但经济花费较高,差异具有统计学意义(P <0.05)。治疗1个月后,观察组家长躯体健康维度、心理健康维度和GQOLI总分3项均较病初明显改善,差异具有统计学意义(P <0.01),而对照组家长上述3项无明显改善,差异无统计学意义(P> 0.05)。结论乳糖酶治疗婴儿生理性腹泻安全有效,且能明显改善家长的躯体和心理健康状态。Objective To observe the therapeutic effects of lactase in infant physiological diarrhea. Methods The clinical data of outpatient infants who presented with physiological diarrhea and received lactase treatment at our hospital from January 2017 to December 2018 were studied retrospectively. The observation group included 73 cases who were treated with lactase, while the control group included 30 cases who were treated with montmorillonite powder alone or combined with probiotics. The cases of the two groups were both followed for more than 3 months to compare the therapeutic effects. One of the parents of each case completed the generic quality of life inventory-74(GQOLI-74). Results The total response rate of the observation group was 100.00%, with a significant improvement rate of 89.04% and improvement rate of 10.96%. The total response rate of the control group was 60.00%, with a significant improvement rate of 46.67% and improvement rate of 13.33%. The total response rate was significantly higher in the observation group than in the control group(P < 0.05). The numbers of hospital visits and stool examinations and the rate of diarrhea associated complications were significantly lower, and the cost was significantly higher in the observation group than in the control group(P < 0.05). The status of physical and psychological health in the parents was significantly improved only in the observation group(P < 0.01), but not in the control group(P > 0.05), a month later. Conclusion Lactase is safe and effective in the treatment of infant physiological diarrhea, which can also improve the status of physical and psychological health in parents.

关 键 词：婴儿 生理性腹泻 乳糖酶 

分 类 号：R725.7[医药卫生—儿科]