右美托咪定联合羟考酮对全身麻醉妇科肿瘤手术患者苏醒期的影响  

Effect of Dexmedetomidine combined with Oxycodone on the waking period of patients undergoing gynecological tumor surgery under general anesthesia

作　　者：邓世辉 王开俊[1] 王洁 DENG Shi-hui;WANG Kai-jun;WANG Jie(Department of Anesthesiology,Luohu People′s Hospital of Shenzhen City,Guangdong Province,Shenzhen 518000,China)

机构地区：[1]深圳市罗湖区人民医院麻醉科

出　　处：《中国当代医药》2020年第2期168-171,共4页China Modern Medicine

摘　　要：目的研究并分析右美托咪定联合羟考酮对全身麻醉妇科肿瘤手术患者苏醒期的影响。方法选取2017年1月~2018年1月于我院接受全身麻醉妇科肿瘤手术的98例患者作为研究对象,按照随机数字表法将其分为四组,其中D组(25例)患者给予右美托咪定,O组(24例)患者给予羟考酮,DO组(24例)患者采用右美托咪定联合羟考酮,C组(25例)患者给予生理盐水。比较四组患者的苏醒时间、拔管时间、拔管后20 min视觉模拟量表(VAS)评分、呛咳评分及苏醒期血清中垂体-靶腺轴相关激素[促甲状腺激素(TSH)、皮质醇(Cor)]水平。结果DO组患者的苏醒时间短于其他三组,差异有统计学意义(P<0.05);DO组患者的拔管时间长于C组,短于D组及O组,差异有统计学意义(P<0.05)。DO组患者拔管后20 min VAS评分低于D组及C组,呛咳评分均低于其他三组,差异有统计学意义(P<0.05)。DO组患者苏醒期血清中TSH、Cor水平均低于其他三组,差异有统计学意义(P<0.05)。结论对于全身麻醉妇科肿瘤手术患者,右美托咪定联合羟考酮可明显缩短患者苏醒时间、拔管时间,降低拔管后VAS、呛咳评分,减少血清中垂体-靶腺轴相关激素含量。Objective To study and analyze the effect of Dexmedetomidine combined with Oxycodone on the waking period of patients undergoing gynecological tumor surgery under general anesthesia.Methods A total of 98 patients who underwent gynecological tumor surgery under general anesthesia in our hospital were selected as the research objects from January 2017 to January 2018,and they were divided into four groups according to the random number table method.Patients in group D(25 cases)were given Dexmedetomidine,patients in group O(24 cases)were given Oxycodone,patients in DO group(24 cases)were given Dexmedetomidine combined with Oxycodone,and patients in group C(25 cases)were given saline.The waking time,extubation time,visual analogue scale(VAS)score at 20 minutes after extubation,cough score and serum pituitary-target gland axis-related hormone(thyroid-stimulating hormone[TSH],cortisol[Cor])levels were compared in the four groups.Results The waking time in the DO group was shorter than that in the other three groups,and the difference was statistically significant(P<0.05).The extubation time in the DO group was longer than that in the group C,and shorter than that in the group D and group O,with statistically significant differences(P<0.05).The VAS score of the patients in the DO group at 20 minutes after extubation was lower than that in the group D and group C,and the cough score was lower than that in the other three groups,with statistically significant differences(P<0.05).The serum levels of TSH and Cor of patients in the DO group were lower than those in the other three groups,and the differences were statistically significant(P<0.05).Conclusion For patients undergoing gynecological tumor surgery under general anesthesia,Dexmedetomidine combined with Oxycodone can significantly shorten the waking time and extubation time,reduce VAS and cough scores after extubation,and reduce the content of pituitary-target gland axis related hormones in serum.

关 键 词：右美托咪定 羟考酮 妇科肿瘤 全身麻醉 苏醒期 

分 类 号：R614[医药卫生—麻醉学]