刺络拔罐联合苯甲酸利扎曲普坦治疗急性发作期偏头痛65例临床研究  

Clinical Efficacy of Collateral Pricking and Cupping Combined with Rizatriptan Benzoate in Treatment of 65 Patients with Acute Episode Migraine

作　　者：张莹[1] 陈劼[1] 张广亮 ZHANG Ying;CHEN Jie;ZHANG Guangliang(Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学

出　　处：《山东中医药大学学报》2020年第1期46-50,共5页Journal of Shandong University of Traditional Chinese Medicine

摘　　要：目的:观察刺络拔罐联合苯甲酸利扎曲普坦口服治疗急性发作期偏头痛的临床疗效及对5-羟色胺(5-HT)、P物质(SP)、同型半胱氨酸(HCY)水平的影响。方法:选取2017年1月至2018年9月在深圳市宝安区中医院针灸科门诊就诊的急性发作期偏头痛患者130例为研究对象,按照随机数字表法分为对照组与观察组,每组65例。对照组予以苯甲酸利扎曲普坦片10 mg口服,日1次;观察组在对照组基础上予刺络拔罐法治疗,5 d 1次,4次为1个疗程;两组均观察20 d。两组治疗前进行24 h生活质量问卷(24 hMQOLQ)评分和疼痛视觉模拟量表(VAS)评分,并于治疗后2 h及24 h进行VAS评分,治疗24 h后进行24 hMQOLQ评分;检测两组治疗前后血清5-HT、SP、HCY的水平。结果:观察组即时疗效有效率87.7%,高于对照组63.1%,差异具有统计学意义(P<0.05);与对照组比较,观察组治疗后24 hMQOLQ评分显著升高,差异有统计学意义(P<0.05);观察组治疗后2 h、24 h的VAS评分均显著低于对照组,差异有统计学意义(P<0.05);观察组SP、HCY水平明显低于对照组,5-HT水平明显高于对照组,差异有统计学意义(P<0.05)。结论:急性发作期偏头痛患者应用刺络拔罐联合苯甲酸利扎曲普坦口服治疗,能快速止痛,减少疼痛发作,显著改善患者生活质量;其作用机制可能与提高血浆5-HT、降低SP及HCY而调节神经-内分泌-炎症因子有关。Objective:To observe the clinical efficacy of collateral pricking and cupping combined with rizatriptan benzoate in the treatment of acute episode migraine and its effect on 5-hydroxytryptamine(5-HT),substance-P(SP)and homocystine(HCY)levels.Methods:A total of 130 patients with acute episode migraine in the outpatient department of acupuncture and moxibustion department of Shenzhen Baoan District Hospital of Traditional Chinese Medicine from January 2017 to September 2018 were selected and divided into the control group and the observation group according to the random number table method,with 65 cases in each group.The control group received 10 mg of rizatripe benzoate tablets orally once a day;the observation group was treated with collateral pricking and cupping on the basis of the control group,once every 5 days,4 times for 1 course,both groups were observed for 20 days.The 24-hour migraine quality of life questionnaire(24 hMQOLQ)score and pain visual analogue scale(VAS)were compared between the two groups before treatment,and the VAS score was performed 2 hours and 24 hours after treatment.After 24 hours of treatment,24 hMQOLQ score was performed;serum 5-HT,SP,HCY levels before and after treatment were measured.Results:The immediate effect rate of the observation group was 87.7%,which was higher than that of the control group(63.1%).The difference was statistical significance(P<0.05).Compared with the control group,the 24 hMQOLQ score of the observation group was significantly increased after treatment.The difference was statistical significance(P<0.05).The VAS scores of the observation group were significantly lower than those in the control group at 2 hours and 24 hours after treatment,the difference was statistical significance(P<0.05).The SP and HCY levels in the observation group were significantly lower than those in the control group while the 5-HT level in the observation group was significant higher compared to that in the control group,the difference was statistical significance(P<0.05).Conclusions

关 键 词：刺络拔罐 苯甲酸利扎曲普坦 偏头痛 急性发作期 5-羟色胺 P物质 同型半胱氨酸 

分 类 号：R277.772[医药卫生—中医学]