益生菌制品消费水平对维持性血液透析患者焦虑及抑郁的影响  

Effect of probiotics consumption level on anxiety and depression in maintenance hemodialysis patients

作　　者：肖晓芬 王晓慧 王静 韩琦 XIAO Xiao-fen;WANG Xiao-hui;WANG Jing;HAN Qi(Department of Clinical Nutrition,Fifth Hospital of Wuhan,Wuhan 430050,China)

机构地区：[1]武汉市第五医院临床营养科,武汉430050 [2]武汉市第五医院肾内科,武汉430050

出　　处：《临床肾脏病杂志》2020年第1期25-29,共5页Journal Of Clinical Nephrology

基　　金：武汉市卫生计生科研基金资助(编号WG17Z06)

摘　　要：目的探讨维持性血液透析(maintenance hemodialysis,MHD)患者益生菌制品消费情况对患者抑郁、焦虑状态的影响。方法纳入MHD患者102例,根据过去半年益生菌制品包括酸奶和肠道微生物制剂消费情况进行分组,运用焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)比较不同组间抑郁、焦虑状态的差异。结果纳入的患者中,酸奶高消费者50例(49.02%),肠道微生物制剂高消费者29例(28.43%),益生菌制品高消费者79例(77.45%);酸奶高消费组患者SAS、SDS评分低于酸奶低消费组,差异有统计学意义(P<0.05);肠道微生物制剂高消费组SAS、SDS评分均低于肠道微生物制剂低消费组,差异有统计学意义(P<0.05);益生菌制品高消费组SAS、SDS评分均低于益生菌制品低消费组,差异有统计学意义(P<0.05);酸奶高消费组SAS、SDS评分均高于肠道微生物制剂高消费组,差异有统计学意义(P<0.05)。结论益生菌制品消费水平越高,MHD患者的SAS、SDS评分越低,合理补充益生菌制品可能可以改善MHD患者焦虑、抑郁状态。益生菌制品对MHD患者情绪影响值得临床关注及进一步探讨。Objective To investigate the different levels of probiotics consumption in patients with maintenance hemodialysis(MHD),and to understand the effect of different consumption levels on their depression and anxiety.Methods A total of 102 patients with MHD were enrolled,and divided into different groups according to the consumption of probiotics including yogurt and intestinal microbial preparations(healthy foods or medicines other than yogurt)in the past six months.The self-rating anxiety scaling(SAS)and the self-rating depression scaling(SDS)were used to compare the differences of anxiety and depression scores between groups.Results Among all the included patients,50 cases were the high-consumption of yogurt(49.02%),29 cases were the high-consumption of intestinal microbial preparations(28.43%),and 79 cases were the high-consumption of probiotics(77.45%).The scores of SAS and SDS in the high-consumption yogurt group were lower than those in the low-consumption group,with statistically significant difference(P<0.05).The scores of SAS and SDS in the high-consumption intestinal microbial preparations group were significantly lower than those in the low-consumption group(P<0.05),and the scores of SAS and SDS in the high-consumption probiotics group also were significantly lower than those in the low-consumption group(P<0.05).The scores of SAS and SDS in the high-consumption yogurt group were significantly higher than those in the high-consumption intestinal microbial preparations group(P<0.05).Conclusions The higher the consumption level of probiotic products,the lower the SAS and SDS scores of MHD patients.Reasonable supplementation of probiotics may relieve the anxiety and depression of MHD patients.And it’s worth paying more attention to and exploring further the effect of probiotics on MHD patients’emotion.

关 键 词：血液透析 益生菌 焦虑 抑郁 

分 类 号：R692.5[医药卫生—泌尿科学]