TCIA患者血清小而密低密度脂蛋白胆固醇的水平及其对TCIA后再发卒中风险的评估价值  

Study the serum small-dense low-density lipoprotein cholesterol levels and its predictive value on the risks of recurrent apoplexy for TCIA patients

作　　者：黄金华 崔显念 姜宜 黄敏 孙家忠[2] HUANG Jinhua;CUI Xiannian;JIANG Yi;HUANG Min;SUN Jiazhong(Department of Clinical Laboratory,TCM Section of the Central Hospital of Enshi Autonomous Prefecture,Enshi,Hubei 445000,China;Department of Clinical Laboratory,Zhongnan Hospital of Wuhan University,Wuhan,Hubei 430000,China)

机构地区：[1]恩施州中心医院中医部检验科,湖北恩施445000 [2]武汉大学中南医院检验科,湖北武汉430000

出　　处：《国际检验医学杂志》2020年第2期159-162,共4页International Journal of Laboratory Medicine

基　　金：2017年度湖北省卫生和计划生育委员会面上项目(WJ2017M033)

摘　　要：目的研究短暂性大脑缺血性发作(TCIA)患者血清小而密低密度脂蛋白胆固醇(sdLDL-C)的水平及其对TCIA后再发卒中风险的评估价值。方法选取恩施州中心医院2017年8月至2018年5月收治的68例TCIA患者作为观察组,另选取同期70例来该院体检健康者作为对照组。采用相关仪器对2组血脂、血压等指标展开对比,分析其相关性。结果与对照组相比,观察组的三酰甘油(TG)、低密度脂蛋白(LDL-C)、血清sdLDL-C水平显著升高,且高密度脂蛋白(HDL-C)、载脂蛋白A1(ApoA1)水平明显降低,差异有统计学意义(P<0.05)。采用ABCD3-Ⅰ评分检测发现68例TCIA患者中,低危组27例,中危组23例,高危组18例。对比3组相关血脂水平,各组间除sdLDL-C水平外,其他血脂指标差异均无统计学意义(P>0.05),其中高危组sdLDL-C水平明显高于中危组与低危组,差异有统计学意义(P<0.05);3组间舒张压(DBP)水平对比差异无统计学意义(P>0.05),但高危组收缩压(SBP)水平明显高于低危组,差异均有统计学意义(P<0.05);sdLDL-C与TC、TG、LDL-C、ApoB及ABCD3-Ⅰ水平呈明显正相关(P<0.05)。结论TCIA患者血清sdLDL-C的水平普遍较高,对预测TCIA后再发卒中风险具有重要的评估价值。Objective To study the level of serum small-dense low-density lipoprotein(sdLDL-C)in patients with transient ischemic attack(TCIA)and its evaluation value on the risk of recurrent stroke after TCIA.Methods A total of 68 TCIA patients admitted to Central Hospital of Enshi Autonomous Prefecture from August 2017 to may 2018 were selected as the observation group,and 70 healthy people who came to the hospital for physical examination in the same period were selected as the control group.The blood lipid,blood pressure and other indexes of the two groups were compared with each other,and the correlation was analyzed.Results Compared with the control group,TG,LDL-C,sdLDL-C,HDL-C and ApoA1 in the observation group were significantly higher,and the difference was statistically significant(P<0.05).Among 68 TCIA patients,27 were in low-risk group,23 in medium-risk group and 18 in high-risk group.Except for sdLDL-C,the other blood lipid index among three groups were not significantly different(P>0.05).sdLDL-C levels in high-risk cases were significantly higher than those of medium-risk and low-risk cases(P<0.05).There was no significant difference in DBP among the three groups(P>0.05),but the SBP level in high-risk group was significantly higher than that in low-risk group(P<0.05);sdLDL-C was positively correlated with TC,TG,LDL-C,ApoB and ABCD3-Ⅰ(P<0.05).Conclusion The level of serum sdLDL-C in patients with TCIA is generally high,which has an important evaluation value for predicting the risk of recurrent stroke after TCIA.

关 键 词：短暂性大脑缺血性发作 血清小而密低密度脂蛋白胆固醇 再发卒中 风险 

分 类 号：R446.6[医药卫生—诊断学] R743.3[医药卫生—临床医学]