临床药师参与1例复杂精神疾病并发消化道出血的药物治疗实践与分析  

Pharmaceutical practice of clinical pharmacist involved in the treatment of a patient with complicated mental diseasescomorbid with gastrointestinal bleeding

作　　者：厉倬学 盛东方 张嘉萱 赵智丽 LI Zhuoxue;SHENG Dongfang;ZHANG Jiaxuan;ZHAO Zhili(Department of Pharmacy,The People’s Hospital of Longhua,Shenzhen,Guangdong 518000,China;Department of Geriatric Psychiatry,Zhongshan Third People’s Hospital,Zhongshan,Guangdong 528400,China;Department of Pharmacy,Zhongshan Third People’s Hospital,Zhongshan,Guangdong 528400,China)

机构地区：[1]深圳市龙华区人民医院药学部,广东深圳518000 [2]中山市第三人民医院老年精神科,广东中山528400 [3]中山市第三人民医院药剂科,广东中山528400

出　　处：《安徽医药》2020年第2期409-413,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨临床药师在复杂精神疾病合并消化道出血治疗时发挥的作用。方法临床药师参与1例精神分裂症和强迫症共病合并消化道出血病人的药物治疗,通过综合分析药效学及循证医学证据,将高出血风险药物改为低受体亲和力及低相互作用风险的药物,并对病人全程实施药学监护。结果临床医师采纳临床药师建议的给药方案,降低了病人的出血风险,减少了药物间相互作用,临床症状显著改善。结论临床药师参与临床药物治疗实践,为病人提供个体化的药学服务,促进临床用药更安全、有效。Objective Toexplore the role of clinical pharmacist in the treatment of complicated mental diseases with gastrointestinalbleeding.Methods The clinical pharmacist was involved in the drug treatment of a patient with schizophrenia and obsessivecompulsive disorder comorbid with gastrointestinal bleeding.On the basis of comprehensive analysis of drugs’ pharmacodynamics and evidence-based medical evidence,the drug with high bleeding risk was changed to the drug with low receptor affinity and low interaction risk.Pharmaceutical monitoring was also carried out throughout the whole treatment process.Results Clinicians adopted the administration regimen recommended by the clinical pharmacist,which reduced the patient’s risk of bleeding and drug-drug interactions,and significantly improved clinical symptoms.Conclusion Clinicalpharmacist’s participation in the clinical drug treatment practice provided individual pharmaceutical care for patient,and promoted safer and more effective use of clinical drugs.

关 键 词：药物疗法管理 精神分裂症 强迫性障碍 胃肠出血 药剂科 医院 舍曲林 米氮平 喹硫平 受体亲和力 药学监护 

分 类 号：R969[医药卫生—药理学]