水杨酸伪麻黄碱对小鼠脑皮层电图的影响  

Effects of Pseudo-ephedrine Salicylate on Central Nervous System by Electrocorticogram in Mice

作　　者：王锐[1] 闫琳[2] 赵迅霞[2] 王红燕[3] 卢宁清[2] 赵玉萍[1] 林枫 WANG Rui;YAN Lin;ZHAO Xunxia;WANG Hongyan;LU Ningqing;ZHAO Yuping;LIN Feng(Department of Pharmacology,School of Pharmacy,Key Laboratory of Ministry of Education in Fertility Preservation and Maintenance,Ningxia Medical University,Yinchuan750004,China;Functional Experimental Teaching Center of Basic Medical Science,Ningxia Medical University,Yinchuan750004,China;Ningxia Human Sperm Bank,the General Hospital of Ningxia Medical University,Yinchuan750004,China;School of Chemistry and Chemical Engineering,Ningxia University,Yinchuan750021,China)

机构地区：[1]宁夏医科大学药学院药理学系,生育力保持教育部重点实验室,银川750004 [2]宁夏医科大学基础医学实验教学示范中心机能实验中心,银川750004 [3]宁夏医科大学总医院宁夏人类精子库,银川750004 [4]宁夏大学化学化工学院,银川750021

出　　处：《宁夏医科大学学报》2019年第12期1207-1210,共4页Journal of Ningxia Medical University

基　　金：国家自然科学基金(81860640);宁夏自然科学基金(NZ17080)

摘　　要：目的探讨水杨酸伪麻黄碱对小鼠皮层脑电活动的影响。方法40只小鼠随机分为4组,分别腹腔注射水杨酸伪麻黄碱25、50、100 mg·kg^-1和生理盐水,采用电生理学方法测定小鼠脑皮层电图总功率(T)、主波频率及频率分配。结果水杨酸伪麻黄碱25 mg·kg^-1组可使小鼠脑皮层电图主波频率在给药后15、30、60、90、120 min升高(P均<0.05);50 mg·kg^-1组可使主波频率仅在给药后5 min升高(P<0.05)。水杨酸伪麻黄碱25 mg·kg-1组给药后5和90 min时可使(α+β)/T升高,(δ+θ)/T降低(P均<0.05);50 mg·kg^-1组在给药后120 min时(δ+θ)/T降低(P<0.05);100 mg·kg^-1组给药后30min时可致δ/T升高(P<0.05),给药后5、15和60 min时θ/T降低(P均<0.05)。各剂量组水杨酸伪麻黄碱对脑电总功率均无明显影响(P均>0.05)。结论水杨酸伪麻黄碱在低剂量时中枢神经兴奋性增强。Objective To investigate the effects of Pseudo-ephedrine Salicylate(PES)on electrocorticogram(ECoG)in mice.Methods Total power,document frequency and frequency distribution were used to observe the change of ECoG in mice administrated with PES.Results Compared with normal saline group,document frequency of the PES(25 mg·kg^-1)treated group was significantly increased after administration 15,30,60,90 and 120min(P all<0.05).After administration for 5min,document frequency of the PES(50 mg·kg^-1)treated group was significantly increased.The ratio sum ofαwave andβwave to total power in the PES(25 mg·kg-1)treated group was significantly increased(P<0.05),meanwhile the ratio sum ofδwave andθwave to total power was decreased(P<0.05)after administration for 5 and 90 min.The ratio sum ofδwave andθwave to total power in the PES(50 mg·kg^-1)treated group was decreased(P all<0.05)after administration for 120min.The ratioδwave to total power in PES(100 mg·kg^-1)treated group was significantly increased(P<0.05)after administration for 5 min,15 min and 60 min,the ratioθwave to total power in PES(100 mg·kg^-1)treated group was decreased(P all<0.05).The total power was not changed in PES(25,50 and 100 mg·kg^-1)treated group(P all>0.05).Conclusion Only low dose of PES has excitability on central nervous system.

关 键 词：水杨酸伪麻黄碱 脑皮层电图 总功率 频率分配 

分 类 号：R96[医药卫生—药理学]