25-羟维生素D3与老年人动脉粥样硬化的关系研究  

Relationship between 25-hydroxyvitamin D3 and atherosclerosis in the elderly

作　　者：刘淘真[1] 王立敏[1] 朱路 邓毅[1] 曾晓琼[1] 李亚民[1] 史兰[1] 柳仙[1] LIU Taozhen;WANG Limin;ZHU Lu;DENG Yi;ZENG Xiaoqiong;LI Yamin;SHI Lan;LIU Xian(Department of Geriatrics,the First People's Hospital of Guiyang City,Guiyang550002,China)

机构地区：[1]贵阳市第一人民医院老年医学科

出　　处：《中国现代医生》2019年第35期8-10,14,共4页China Modern Doctor

基　　金：贵州省科学技术基金项目（黔科合J字[2013]2018号）

摘　　要：目的研究25-羟维生素D3[25(OH)D3]与老年人动脉粥样硬化的相关性。方法选择2013年4月~2019年5月间我院老年医学科收治的577例老年心脑血管患者为研究对象。所有人均空腹抽血查25-羟维生素D3,根据维生素D3检查结果分为缺乏、不足、正常三组。同时对所有患者进行详细的病史采集、体格检查、常规辅助检查(肝肾功、尿酸、电解质等),检测研究对象的血管脉搏波传导速度及踝背指数。比较三组患者一般情况、体质量指数(BMI)、尿酸(UA)、磷(P)、血清钙(Ca)、血管脉搏波传导速度及踝背指数、血清25(OH)D3等指标,经Logistic回归分析法总结动脉粥样硬化致病的危险因素。结果三组患者在性别、BMI、血Ca、血P方面比较差异无显著性(P>0.05);而在年龄、UA、25(OH)D3方面比较差异有显著性(P<0.05)。以是否合并周围血管动脉粥样硬化作因变量,以年龄、UA、25(OH)D3要素作自变量,经Logistic回归分析明确年龄、UA为老年心血管病动脉粥样硬化的独立危险因素,而25(OH)D3为保护因素。结论25(OH)D3有助于减少老年心血管病动脉粥样硬化的发生,是保护因素;年龄及血UA为老年人动脉粥样硬化的独立危险因素,故在实际治疗中,可从这三方面入手,以防治动脉粥样硬化病变,降低心脑血管病的发生率。但针对血清25(OH)D3与血UA是否具有相关性,临床仍需进一步研究与证实。Objective To study the correlation between 25-hydroxyvitamin D3[25(OH)D3]and atherosclerosis in the elderly.Methods A total of 577 elderly patients with cardiovascular and cerebrovascular diseases admitted to the Department of Geriatrics of our hospital from April 2013 to May 2019 were enrolled.Fasting blood was detected in all the patients to check the 25-hydroxyvitamin D3 levels,based on which the patients were divided into three groups,namely lack group,deficiency group and normal group.At the same time,all the patients were subjected to detailed medical history collection,physical examination,routine auxiliary examination(liver and kidney function,uric acid,electrolytes,etc.),and vascular pulse wave velocity and ankle brachial pressure index detection.The general conditions,body mass index(BMI),uric acid(UA),phosphorus(P),serum calcium(Ca),vascular pulse wave velocity and ankle brachial pressure index and serum 25(OH)D3 indicators in the three groups were compared.The regression analysis was used to summarize the relationship of the pathogenic factors of atherosclerosis.Results There were no significant differences in gender,BMI as well as serum Ca and P among the three groups(P>0.05).There were significant differences in age,UA and 25(OH)D3 among the three groups(P<0.05).With whether complicated by atherosclerosis or not as dependent variable and with age,UA and 25(OH)D3 as independent variables,it was determined by Logistic regression analysis that the age,UA were independent risk factors for atherosclerosis and 25(OH)D3 was a protective factor.Conclusion 25(OH)D3 can help to reduce the incidence of atherosclerosis in elderly cardiovascular diseases,which was a protective factor.Age and blood UA are all independent risk factors for atherosclerosis in the elderly.In the actual treatment.In the actual treatment,we can start from these three aspects to prevent and treat atherosclerotic lesions and reduce the incidence of cardiovascular and cerebrovascular diseases.However,whether serum 25(OH)D3 is related to b

关 键 词：25-羟维生素D3 老年 动脉粥样硬化 关系 

分 类 号：R587.2[医药卫生—内分泌]