2型糖尿病患者趾臂指数与颈动脉及下肢动脉内中膜厚度的相关性研究  

The relationship between toe brachial index and carotid,lower extremity aterial intimal-medial thickness in patients with type 2 diabetes

作　　者：唐旖阳 周海成[1] 朱雅琳 邢倩[1] 巴颖[1] 杨郁[1] 杜建玲[1] TANG Yiyang;ZHOU Haicheng;ZHU Yalin;XING Qian;BA Ying;YANG Yu;DU Jianling(Department of Endocrinology,the First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China;Second Department of Ultrasonography,the First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China)

机构地区：[1]大连医科大学附属第一医院内分泌科,辽宁大连116011 [2]大连医科大学附属第一医院超声二科,辽宁大连116011

出　　处：《检验医学与临床》2020年第2期165-169,共5页Laboratory Medicine and Clinic

摘　　要：目的分析2型糖尿病(T2DM)患者趾臂指数(TBI)与外周动脉内中膜厚度(IMT)的相关性及TBI降低的危险因素。方法选择该院内分泌科住院的T2DM患者292例作为研究对象,分析其TBI与颈、股、腘动脉IMT的相关性及TBI降低的危险因素。结果 TBI降低组(TBI<0.7)与TBI正常组(TBI≥0.7)比较,年龄,DM病程,收缩压(SBP),颈、股、腘动脉IMT,DN患病人数差异均有统计学意义(P<0.05);TBI与颈、股、腘动脉IMT均呈负相关(r=-0.331、-0.288、-0.350,P<0.001);TBI降低的危险因素为年龄(OR=1.060、P<0.001、95%CI:1.027~1.095)、DM病程(OR=1.073、P=0.001、95%CI:1.027~1.121)、SBP(OR=1.021、P=0.018、95%CI:1.004~1.039)和吸烟史(OR=2.406、P=0.008、95%CI:1.251~4.626)。结论 T2DM患者TBI与颈、股、腘动脉IMT均呈负相关,年龄、糖尿病病程、SBP和吸烟史是TBI降低的危险因素。Objective To evaluate to investigate the relationship between toe arm index(TBI)and arterial intima-media thickness(IMT),as well as the risk factors associated with the reducing of TBI among type 2 diabetes patients.Methods A total of 292 inpatients diagnosed for type 2 diabetes in the first Affiliated Hospital of Dalian Medical University were investigated.The risk factors associated with the reducing of TBI was evaluated by Logistic regression.The relationship between TBI and IMT was also evaluated.Results The patients with TBI<0.7 defined as low TBI group,whereas the patients with TBI≥0.7 defined as normal TBI group,there were significant difference on age,duration of diabetes,systolic blood pressure(SBP),carotid IMT,femoral arterial IMT,popliteal arterial IMT,rate of diabetic nephropathy between the two groups(P<0.05).According to Spearman correlation analysis,TBI negative correlated with carotid IMT,femoral arterial IMT and popliteal arterial IMT(r=-0.331,r=-0.288,r=-0.350,P<0.001).Risk factors of reducing of TBI were age(OR=1.060,P<0.001,95%CI:1.027-1.095),duration of diabetes(OR=1.073,P<0.001,95%CI:1.027-1.121),SBP(OR=1.021,P=0.018,95%CI:1.004-1.039)and smoking history(OR=2.406,P=0.008,95%CI:1.251-4.626).Conclusion In type 2 diabetes,TBI and carotid,femoral,popliteal arterial IMT negatively correlated,the risk factors of the reducing of TBI are age,duration of diabetes,SBP and smoking history.

关 键 词：2型糖尿病 趾臂指数 外周动脉病变 动脉内中膜厚度 

分 类 号：R587.1[医药卫生—内分泌]