冠心病患者血清Lp(a）、NEFA水平变化及临床意义  

Change and clinical significance of serum Lp(a) and NEFA levels in patients with coronary heart disease

作　　者：李名鹏[1] 史廷枫 郭子安 郭满容[1] 王仲华[1] LI Mingpeng;SHI Tingfeng;GUO Zi′an;GUO Manrong;WANG Zhonghua(Department of Cardiovascular Medicine,Chenzhou First People′s Hospital,Hu′nan Province,Chenzhou423000,China)

机构地区：[1]湖南省郴州市第一人民医院心血管内科

出　　处：《中国医药导报》2020年第2期61-64,共4页China Medical Herald

基　　金：湖南省重点研发计划;创新平台与人才计划项目(2015JC3131)

摘　　要：目的分析冠心病(CHD)患者血清脂蛋白a(Lpa)、游离脂肪酸(NEFA)水平变化及临床意义。方法选取2016年5月~2019年1月湖南省郴州市第一人民医院确诊的CHD患者143例为研究组,依据病变支数将其分为单支病变亚组(54例)、双支病变亚组(49例)和多支病变亚组(40例)。依据Gensini积分将其分为低分亚组(34例),中分亚组(47例),高分亚组(62例)。选择同期入院行冠脉造影检查显示单支轻度狭窄且冠状动脉阻塞程度<30%的患者106例为对照组。比较两组血清Lp(a)和NEFA水平。Pearson相关分析Lp(a)、NEFA水平与病变支数、Gensini积分及Lp(a)与NEFA的相关性。结果研究组血清Lp(a)、NEFA水平高于对照组,差异均有统计学意义(均P<0.05)。研究组血清Lp(a)、NEFA水平随着冠状动脉病变支数及病变程度增加而升高(P<0.05)。Pearson相关性分析显示,CHD患者血清Lp(a)、NEFA水平与Gensini积分呈正相关(r=0.482、0.503,P<0.05);血清Lp(a)、NEFA水平与病变支数呈正相关(r=0.513、0.472,P<0.05);血清Lp(a)与NEFA呈正相关(r=0.469、P<0.05)结论CHD患者血清Lp(a)、NEFA水平显著增高,与患者病变血管支数和Gensini积分呈正相关,Lp(a)、NEFA的检测对CHD患者临床诊疗具有重要意义。s]Objectives To analyze the change and clinical significance of serum lipoprotein a[Lp(a)]and non-esterified fatty acid(NEFA)levels in patients with coronary heart disease(CHD).Methods From May 2016 to January 2019,143 cases with CHD diagnosed in Chenzhou First People′s Hospital of Hu′nan Province were selected as the study group.According to the lesion branch,they were divided into single branch lesion subgroup(54 cases),double branch lesion subgroup(49 cases)and multi-branch lesion subgroup(40 cases).According to Gensini scores,they were divided into low score subgroup(34 cases),middle score subgroup(47 cases)and high score subgroup(62 cases).And 106 patients who underwent coronary angiography at the same time,with mild stenosis and coronary artery occlusion less than 30%were selected as the control group.Serum Lp(a)and NEFA levels were compared between the two groups.Pearson correlative analysis was used to analysed the correlation between Lp(a),NEFA levels and lesion branch,Gensini scores,the level of Lp(a)and NEFA.Results The serum levels of Lp(a)and NEFA in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The levels of serum Lp(a)and NEFA in the study group increased with the number of coronary artery lesion branchesand the degree of lesions(P<0.05).Pearson correlative analysis showed that serum Lp(a)and NEFA levels were positively correlated with Gensini scores(r=0.482,0.503,P<0.05).Serum Lp(a)and NEFA levels were positively correlated with the number of lesions(r=0.513,0.472,P<0.05).The serum Lp(a)in CHD patients was positively correlated with NEFA(r=0.469,P<0.05).Conclusion The levels of serum Lp(a)and NEFA in CHD patients are significantly increased,and are positively correlated with the number of lesions and Gensini scores.The detection of Lp(a)and NEFA are of great significance for the clinical diagnosis and treatment of CHD patients.

关 键 词：冠心病 脂蛋白A 游离脂肪酸 

分 类 号：R541.4[医药卫生—心血管疾病]