阿尔茨海默病患者血清硫氧还蛋白和褪黑激素水平与简易智力状态检查量表评分的相关性研究  

Association of serum thioredoxin and melatonin levels with MMSE score in patients with Alzheimer’s disease

作　　者：张雨桐 王晟东[2] 李静 宋明芬[2] 王姝琪 闫盼 ZHANG Yutong;WANG Shengdong;LI Jing(Molecular Biology Laboratory,Hangzhou Seventh People’s Hospital,Hangzhou 310013,China)

机构地区：[1]杭州市第七人民医院科教科,310013 [2]杭州市第七人民医院分子生物学实验室,310013

出　　处：《浙江医学》2020年第1期48-50,75,共4页Zhejiang Medical Journal

基　　金：浙江省自然科学基金项目(LY17H090013)

摘　　要：目的通过检测血清中硫氧还蛋白和褪黑激素水平,比较分析其与阿尔茨海默病的相关性。方法利用简易智力状态检查量表(MMSE)将研究对象分为阿尔茨海默病组、轻度认知功能障碍组和健康对照组,其中阿尔茨海默病组31例,轻度认知功能障碍组28例,健康对照组40例。检测并比较3组血清硫氧还蛋白和褪黑激素水平,分析阿尔茨海默病组血清硫氧还蛋白和褪黑激素水平与MMSE评分相关性。结果阿尔茨海默病组血清硫氧还蛋白和褪黑激素水平显著低于健康对照组(P<0.01)。阿尔茨海默病组血清硫氧还蛋白水平、褪黑激素水平与MMSE评分均呈正相关(r=0.4388、0.5564,均P<0.05)。结论血清硫氧还蛋白水平和褪黑激素水平可在一定程度上反映阿尔茨海默病的病情严重程度。硫氧还蛋白和褪黑激素是阿尔茨海默病潜在的治疗靶点。Objective To investigate the association of serum thioredoxin(Trx)and melatonin(MT)levels with mini-mental state examination(MMSE)scores in patients with Alzheimer’s disease(AD).Methods Thirty one patients with Alzheimer’s disease(AD group),28 patients with mild cognitive impairment(MCI group)and 40 healthy subjects(control group)were recruited in the study.The serum Trx and MT levels of the three groups were measured,and the correlation of serum Trx and MT levels with MMSE scores in AD patients was analyzed.Results The serum Trx and MT levels in AD group were significantly lower than those in control group(P<0.01).The serum Trx and MT levels were correlated with MMSE scores in AD patients(r=0.4388,P=0.0135;r=0.5564,P=0.0012).Conclusion Serum Trx and MT levels are associated with the severity of Alzheimer’s disease.

关 键 词：硫氧还蛋白 褪黑激素 阿尔茨海默病 简易智力状态检查量表 

分 类 号：R749.16[医药卫生—神经病学与精神病学]