血尿酸水平与急性冠脉综合征患者短期预后的相关性分析  

Correlation between serum uric acid level and short-term prognosis in patients with acute coronary syndrome

作　　者：符武岛 李伟[1] 郑茵[1] 陈娟[1] 冯光球[1] 戴文鑫[1] 管频[1] 周菲[2] FU Wudao;LI Wei;ZHENG Yin(Department of Health Center,Hainan General Hospital,Haikou 570311,China)

机构地区：[1]海南省人民医院医疗保健中心,海口570311 [2]海南省人民医院心内科,海口570311

出　　处：《浙江医学》2020年第1期54-58,共5页Zhejiang Medical Journal

摘　　要：目的探讨血尿酸(UA)水平与急性冠脉综合征(ACS)患者180d内预后的相关性。方法回顾性分析2016年1月至2018年5月在心内科、医疗保健中心住院诊治的ACS患者1548例,入院时收集血液样本测UA浓度。根据UA水平将患者分为4组。使用多因素logistic回归分析评估UA水平与ACS患者临床结果的关系。结果总研究对象1548例,新发ACS 1197例,其中院内死亡29例(28例是院内新发ACS死亡),失访88例,最终有180d随访结果的为1431例,其中新发ACS患者1088例。将UA作为变量,UA>357μmol/L,能明显增加总体人群和新发ACS人群的院内死亡风险(均P<0.01),校正相关变量(模型1、模型2)后仍有明显统计学意义(均P<0.05)。院内死亡患者的UA与C反应蛋白(CRP)水平呈正相关(r=0.41,P<0.05),而180d存活患者和出院后死亡患者UA与CRP水平均无相关性(r=0.045、0.048,均P>0.05)。结论在ACS患者中,UA水平高于357μmol/L与院内死亡率相关。Objective To investigate the correlation between serum uric acid(UA) level and the short-term prognosis in patients with acute coronary syndrome(ACS). Methods Clinical data of patients with acute coronary syndrome admitted in the Department of Cardiovascular Medicine and Healthcare Center of our hospital from January 2016 to May 2018 were retrospectively analyzed. Blood samples were collected upon admission, and serum uric acid concentrations were measured. Multivariate Logistic regression analysis was used to assess the relationship between serum uric acid levels and clinical outcomes in patients with ACS. Results Among 1 548 ACS cases there were 1 197 were new cases;in-hospital deaths occurred in 29 cases of which 28 were new ACS cases;eventually 1 431 cases were followed up for 180 days of which 1088 were new ACS patients. Logistic regression analysis showed that serum UA>357μmol/L significantly increased the risk of in-hospital mortality in ACS patients, before and after adjusting for related variables(model 1, model 2)(all P<0.05). There was a positive correlation between serum UA and CRP levels in patients who died in hospitalization(r=0.41, P<0.05), but there was no correlation between serum UA and CRP levels in 180-day surviving patients and patients who died after discharge(r=0.045, 0.048, all P>0.05). Conclusion In patients with acute coronary syndrome, serum uric acid levels above 357μmol/L are associated with in-hospital mortality.

关 键 词：急性冠脉综合征 血尿酸 短期预后 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]