80例过敏性皮肤病患者血清IgE与嗜酸性粒细胞的检测结果分析  

Analysis of serum IgE and eosinophils in 80 patients with allergic dermatosis

作　　者：李沂轩[1] 王莉[1] 贺雪文[1] 侯爱华[1] LI Yi-xuan;WANG Li;HE Xue-wen;HOU Ai-hua(Department of Dermatology,Shanghai Yangpu District Shidong Hospital,Shanghai 200438,China)

机构地区：[1]上海市杨浦区市东医院皮肤科

出　　处：《皮肤性病诊疗学杂志》2019年第6期327-331,共5页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的:探讨血清免疫球蛋白E(IgE)及嗜酸性粒细胞(EOS)与不同类型过敏性皮肤病的关系。方法:选取本院接诊的80例过敏性皮肤病患者(观察组)和80例健康体检者(对照组)作为研究对象,采集空腹静脉血测定血清总IgE及EOS水平,对比分析检测结果。结果:观察组血清IgE水平、EOS计数、血清IgE阳性率、EOS阳性率明显高于对照组(P值均<0.05)。比较不同类型过敏性皮肤病的血清IgE水平、EOS计数、IgE阳性率及EOS阳性率,差异均有统计学意义(P值均<0.05);其中过敏性紫癜组各项水平最低,湿疹组水平最高,差异均有统计学意义(P值均<0.05)。相关分析显示过敏性皮肤病患者血清IgE水平与EOS计数无明显相关性(r=0.16,P>0.05)。结论:过敏性皮肤病的发生与血清IgE及EOS的高表达有关,不同类型过敏性皮肤病的血清IgE、EOS表达差异明显,临床应根据各过敏性皮肤病的血清IgE、EOS表达特点合理制定免疫球蛋白治疗方案。Objective:To explore the relationship between serum immunoglobulin E(IgE)and eosinophil(EOS)and different types of allergic skin diseases.Methods:Eighty cases of allergic dermatosis and 80 cases of health examination respectively were enrolled in the observation group and the control group.Fasting venous blood was collected and serum total IgE and EOS levels were measured.The results were compared and analyzed.Results:The levels of serum IgE and EOS in the observation group were significantly higher than those in the control group,and the positive rates of serum IgE and EOS were also significantly higher(P<0.05).There were significant differences in serum IgE level,EOS count,IgE positive rate and EOS positive rate among different types of allergic skin diseases(P<0.05).Serum IgE level,EOS count,IgE positive rate and EOS positive rate were the lowest in allergic purpura group,while they were the highest in eczema group.There was no significant correlation between serum IgE and EOS counts in patients with allergic dermatosis(r=0.16,P>0.05).Conclusion:The occurrence of allergic skin diseases is related to the high expression of serum IgE and EOS.The expression of serum IgE and EOS in different types of allergic skin diseases is significantly different.The clinical treatment plan of immunoglobulin should be reasonably formulated according to the expression characteristics of serum IgE and EOS in allergic skin diseases.

关 键 词：过敏性皮肤病 血清免疫球蛋白E 嗜酸性粒细胞 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]