新型氮杂环卡宾钯催化剂的合成及应用  

Synthesis and Application of A Novel N-heterocyclic Carbene Palladium Catalyst

作　　者：乔玉辉 彭丽君 何谦 黄晴菲[1] 黄冲 王启卫[1] QIAO Yu-hui;PENG Li-jun;HE Qian;HUANG Qing-fei;HUANG Chong;WANG Qi-wei(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;University of Chinese Academy of Sciences,Beijing 100049,China;Changzhou Institute of Chemistry,Changzhou 213000,China;College of Chemistry&Environment Protection Engineering,Southwest Minzu University,Chengdu 610041,China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]中国科学院大学,北京100049 [3]常州化学研究所,江苏常州213000 [4]西南民族大学化学与环境保护工程学院,四川成都610041

出　　处：《合成化学》2020年第1期25-29,共5页Chinese Journal of Synthetic Chemistry

基　　金：常州市应用基础研究计划(CJ20180011);中科院“西部之光”人才培养计划

摘　　要：以对甲基苯胺和二苯甲醇为原料,设计并合成了饱和氮杂卡宾(SIPr*),并与金属钯络合制得催化剂(SIPr*)Pd(cin)Cl。将催化剂用于Suzuki-Miyaura偶联反应研究了其活性。结果表明:在反应条件(以氢氧化钾为碱,二氧六环为溶剂,0.5 mol%催化剂,于110℃反应30 min)下拓展了20种底物,收率均较高,TOF可达792 h-1。The saturated N-heterocyclic carbine(SIPr*)was designed and synthesized from p-methylaniline and diphenylmethanol.The catalyst(SIPr*)Pd(cin)Cl was prepared by complexing reaction of SIPr*with palladium,and the catalyst was used to catalyze Suzuki-Miyaura cross-coupling reaction.The result indicated that under the conditions(potassium hydroxide as the basic medium and dioxane as the solvent,0.5 mol%catalyst and reaction at 110℃for 30 min),twenty substrates were developed with good yields.The TOF can reach up to 792 h-1.

关 键 词：对甲基苯胺 二苯甲醇 氮杂环卡宾 钯络合物 合成 偶联 催化性能 

分 类 号：O626.2[理学—有机化学]