新型吡唑啉酮-六氢山酮素-氧化吲哚衍生物的合成  

Synthesis of Novel Pyrazolone-hexahydroxanthone-spirooxindole Derivatives

作　　者：姜维艳 岳静 刘雄利[2] 邓国栋[2] JIANG Wei-yan;YUE Jing;LIU Xiong-li;DENG Guo-dong(Guizhou Equipmet Manufacturing Vocational College,Guiyang 550025,China;Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州装备制造职业学院,贵州贵阳550025 [2]贵州大学贵州省药食同源植物资源开发工程技术研究中心,贵州贵阳550025

出　　处：《合成化学》2020年第1期46-52,共7页Chinese Journal of Synthetic Chemistry

基　　金：黔科合平台人才项目([2018]5781)

摘　　要：以色酮-吡唑啉酮合成子与3-烯键氧化吲哚为原料,DABCO为催化剂,氯仿为溶剂,于室温发生分子间Michael加成反应后再发生分子内环化反应,合成了14个未见文献报道的吡唑啉酮六氢山酮素骨架拼接氧化吲哚3a^3n,产率75%~89%,dr值7/1~11/1,其结构经1 H NMR,13 C NMR和HR-MS(ESI-TOF)表征。Fourteen novel pyrazolone-fused hexahydroxanthone-based spirooxindoles(3a^3n)were synthesized via an DABCO-catalyzed dual Michael cycloaddition of pyrazolone-chromone synthons with methyleneoxindoles under room temperature conditions.The yields and dr of 3a^3n were 75%~89%and 7/1~11/1,respectively.The structures were characterized by 1 H NMR,13 C NMR and HR-MS(ESI-TOF).

关 键 词：色酮-吡唑啉酮合成子 3-烯键氧化吲哚 双Michael加成反应 吡唑啉酮六氢山酮素骨架拼接氧化吲哚 合成 

分 类 号：O626.13[理学—有机化学] O623.7[理学—化学]