新型1-取代-2-(1′,3′-二氧五环-4′-基)苯并咪唑的合成  

Synthesis of 1-Substituent-2-(1′,3′-Dioxolan-4-yl) Benzimidazole

作　　者：吕松[1] 李伟光[1] 袁斌[1] LV Song;LI Wei-guang;YUAN Bin(Faculty of Environmental Science and Engineering,Guangdong University of Technology,Guangzhou,510006,China)

机构地区：[1]广东工业大学环境科学与工程学院

出　　处：《合成化学》2020年第1期58-61,共4页Chinese Journal of Synthetic Chemistry

基　　金：广东省科技计划项目(2016A020221035)

摘　　要：以地沟油水解副产物甘油和多聚甲醛为原料,经醇醛缩合和次氯酸钠催化氧化反应制得1,3-二氧杂环戊-4-酸(DIC);DIC与邻苯二胺或其衍生物进行酰胺化-环化反应高效地合成了3种新型的1-取代-2-(1′,3′-二氧五环-4′-基)苯并咪唑类化合物,其结构经UV-Vis,1 H NMR,13 C NMR,IR和GC-MS表征。1,3-Dioxolan-4-carboxylic acid(DIC)was prepared by aldol condensation and catalytic oxidation of sodium hypochlorite using glycerol,a byproduct of hydrolysis of gutter oil,and polyformaldehyde as raw materials.Three novel 1-N-substituent-2-(1′,3′-dioxolan-4-yl)benzimidazole were synthesized by one-pot acylation-cyclization reaction of DIC with o-phenylendiamine or its derivatives in xylene medium,respectively.The structures were characterized by UV-Vis,1 H NMR,13 C NMR,IR and GC-MS.

关 键 词：甘油 多聚甲醛 苯并咪唑 1 3-二氧杂环戊-4-酸 合成 

分 类 号：O626.23[理学—有机化学]