冠心病合并2型糖尿病患者致血浆动脉粥样硬化指数与SYNTAX评分相关性研究  

Relationship between atherogenic index of plasma and SYNTAX score in patients with coronary artery disease and type 2 diabetes mellitus

作　　者：冯仕勇[1] 许勇[1] 陈晓玲[1] 边晓菊 刘茂兰 何芙蓉 FENG Shiyong;XU Yong;CHEN Xiaoling;BIAN Xiaoju;LIU Ma-olan;HE Furong(Department of Cardiology,The Second People's Hospital of Deyang,Sichuan 618000,China)

机构地区：[1]四川省德阳市第二人民医院心内科

出　　处：《心肺血管病杂志》2019年第12期1209-1212,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:分析冠心病合并2型糖尿群中,血浆致动脉粥样硬化指数(AIP)与SYNTAX评分的相关性,探讨AIP对冠状动脉病变严重程度的预测价值。方法:回顾性分析2017年1月至2019年6月期间,经冠状动脉造影确诊为冠心病的2型糖尿病患者578例,根据AIP四分位数将其分为四组(Ⅰ组:≤0.16,Ⅱ组:0.17~0.31,Ⅲ组:0.32~0.44,Ⅳ组:≥0.45),比较各组患者的临床资料,应用Logistic回归模型对AIP水平及SYNTAX评分进行相关性分析。结果:随着AIP的上升,SYNTAX评分逐渐升高[Ⅰ组:(13.84±6.90),Ⅱ组:(15.92±7.37),Ⅲ组:(16.23±8.39),Ⅳ组:(18.27±7.86),P<0.001],Logistic回归分析调整混杂因素后发现,Ⅱ组-Ⅳ组相对于Ⅰ组的优势比分别为1.390、2.120、2.790,趋势性检验示P<0.001。结论:AIP与冠心病合并2型糖尿病的患者SYNTAX评分密切相关,可作为冠状动脉病变复杂程度的一个重要预测指标。Objective:To investigate the relationship between atherogenic index of plasma(AIP)and SYNTAX score in patients with coronary artery disease and type 2 diabetes mellitus.Methods:Between January 2017 and June 2019,578 diabetic patients with angiographically confirmed coronary artery disease in our hospi-tal were retrospectively analyzed.Patients were divided into 4 groups according to quartiles of AIP values(groupⅠ:≤0.16,groupⅡ:0.17-0.31,groupⅢ:0.32-0.44,groupⅣ:≥0.45).Logistic regression analysis(with forced entry method)was performed to examine the relationship between AIP values and SYNTAX score.Results:The association between higher AIP quartiles and a higher SYNTAX score was observed [groupⅠ:(13.84±6.90),groupⅡ:(15.92±7.37),groupⅢ:(16.23±8.39),groupⅣ:(18.27±7.86),P<0.001].After adjusting for age,gender,body mass index,smoking,dyslipidemia,creatinine,fasting plasma glucose and uric acid values,Logistic regression analysis showed that when compared with groupⅠ,the odds ratios of groupⅡ-Ⅳwere 1.390,2.120,2.790 respectively(P for trend<0.001).Conclusions:AIP is posi-tively associated with SYNTAX score and should be regarded as an important predictor for coronary artery dis-ease severity.

关 键 词：冠心病 2型糖尿病 血浆致动脉粥样硬化指数 SYNTAX评分 

分 类 号：R54[医药卫生—心血管疾病]