儿童肺炎伴惊厥的炎症指标及影响因素研究  

Study on the indicators and influencing factors of childhood pneumonia with convulsive inflammation

作　　者：黄丹丹[1] 张小白[1] HUANG Dandan;ZHANG Xiaobai(Department of Pediatrics,First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003,China)

机构地区：[1]河南科技大学第一附属医院儿科

出　　处：《现代医药卫生》2020年第3期339-342,共4页Journal of Modern Medicine & Health

摘　　要：目的分析儿童肺炎伴惊厥的炎症指标及影响因素,为今后临床肺炎伴惊厥的诊断、治疗和检测提供科学理论依据。方法选取该院儿科2016年12月至2018年12月收治的儿童社区获得性肺炎患儿167例作为研究对象,其中78例社区获得性肺炎伴惊厥患儿设为病例组,89例社区获得性肺炎不伴惊厥患儿设为对照组,同时选取同期正常入学的90例健康儿童为健康组。通过分析三组受试者血清C反应蛋白(CRP)水平、中性粒细胞百分比分类(N%)、白细胞计数、血清降钙素原(PCT)、红细胞沉降率(ESR)、乳酸脱氢酶(LDH)等炎症指标及通过相关统计分析找出引起儿童肺炎伴惊厥的危险因素,并对潜在诱发疾病的相关因素行多因素logistics统计分析。结果病例组CRP、N%、白细胞计数、PCT、ESR、LDH等实验室相关炎症指标与对照组、健康组比较,差异均有统计学意义(P<0.05)。住院时间大于或等于14 d[比值比(OR)=3.26,95%可信区间(95%CI):1.42~6.93]、发病年龄小于3岁(OR=4.83,95%CI:1.22~9.78)、一级亲属惊厥发作史(OR=4.52,95%CI:1.36~7.45)、使用抗生素种类大于或等于3种(OR=2.62,95%CI:0.76~4.39)、体温大于或等于38℃(OR=5.19,95%CI:0.84~4.22)、癫痫史(OR=3.38,95%CI:0.91~5.57)、低钠血症(OR=3.74,95%CI:1.54~6.38)均是儿童肺炎伴惊厥的独立危险因素(P<0.05)。结论针对以上儿童肺炎伴惊厥的独立危险因素,应尽早完善相关的血象及外周血生化、入院脑电图检查,必要时行脑脊液和头颅影像学等检查,及时明确惊厥相关发病原因,从而给予相应科学的治疗和预防措施。Objective To analyze the current indicators and influencing factors of childhood pneumonia with convulsion,and to provide scientific theoretical basis for the diagnosis,treatment and detection of clinical pneumonia with convulsion in the future.Methods A total of 167 children with community-acquired pneumonia admitted to the department of pediatrics from December 2016 to December 2018 were selected as study subjects.Among them,78 cases of community-acquired pneumonia with convulsion were set as the case group,89 cases of community-acquired pneumonia without convulsion were set as the control group,and 90 healthy children enrolled in normal school in the same period were selected as the healthy group.By analyzing the levels of serum C-reactive protein(CRP),percentage classification of neutrophils(N%),white blood cell count,serum procalcitonin(PCT),erythrocyte sedimentation rate(ESR),lactate dehydrogenase(LDH)and other inflammatory indicators in the three groups of subjects,the risk factors of convulsion in children with pneumonia were found out through relevant statistical analysis,and logistic statistical analysis was conduct on potential factors leading to disease.Results Compared with the control group and the healthy group,the differences in laboratory-related inflammatory indicators(CRP,N%,WBC count,PCT,ESR,LDH)in the case group were statistically significant(P<0.05).Duration of hospitalization was greater than or equal to 14 d[odds ratio(OR)=3.26,95%confidence interval(95%CI):1.42-6.93];age of onset less than 3 years old(OR=4.83,95%CI:1.22-9.78);history of first-degree relative seizure(OR=4.52,95%CI:1.36-7.45);use of antibiotics of greater than or equal to 3(OR=2.62,95%CI:0.76-4.39),body temperature greater than or equal to 38℃(OR=5.19,95%CI:0.84-4.22),epilepsy(OR=3.38,95%CI:0.91-5.57),and hyponatremia(OR=3.74,95%CI:1.54-6.38)were independent risk factors for pneumonia with convulsion in children(P<0.05).Conclusion In view of the above independent risk factors for pneumonia with convulsion in children.Rele

关 键 词：儿童肺炎 惊厥 炎症指标 影响因素 

分 类 号：R725.6[医药卫生—儿科]