Irisin与多囊卵巢综合征代谢紊乱的研究进展  

Research Progress on Irisin and Metabolic Disorders of Polycystic Ovary Syndrome

作　　者：李杨[1] 闫洪亮 胡同秀 尚玉敏[1] LI Yang;YAN Hong-liang;HU Tongxiu;SHANG Yu-min(Department of Obstetrics and Gynecology,Tianjin Hospital,Tianjin 300211,China)

机构地区：[1]天津医院妇产科

出　　处：《国际妇产科学杂志》2020年第1期88-91,共4页Journal of International Obstetrics and Gynecology

基　　金：天津市天津医院科技基金（1801）

摘　　要：多囊卵巢综合征(PCOS)是育龄期妇女常见的生殖障碍及代谢功能紊乱性疾病,常伴有肥胖、胰岛素抵抗、雄激素过多和血脂异常等代谢异常,PCOS代谢紊乱比单纯的生殖障碍更复杂。鸢尾素(Irisin)为新近发现的在PCOS患者体内异常表达的肌肉因子,其主要作用机制为诱导白色脂肪组织的"褐变",增加产热和能量消耗,已有研究表明Irisin在肥胖、2型糖尿病、脂质代谢和心血管疾病、非酒精性脂肪肝等代谢障碍性疾病中发挥保护作用,但Irisin在PCOS的发生、发展中的作用尚不明确。本文综述Irisin在PCOS患者代谢紊乱发病机制中的作用,为PCOS的诊治提供新思路。Polycystic ovary syndrome(PCOS) is a common reproductive and metabolic disorder in women of childbearing age. It is often accompanied by metabolic abnormalities such as obesity, insulin resistance, androgen excess, and dyslipidemia. The metabolic disorder of PCOS is more complicated than simple reproductive disorders. Newly discovered myokine-Irisin is abnormally expressed in PCOS patients, which mainly induces "browning" of white adipose tissue, thereby increasing heat production and energy consumption. Previous studies shows that Irisin plays a protective role in obesity, type Ⅱ diabetes, lipid metabolism and cardiovascular diseases, non-alcoholic fatty liver and other metabolic disorders, but its role in the study of the occurrence and progression of PCOS disease is still unclear. Learning the role of Irisin in the pathogenesis of metabolic disorders in patients with PCOS provides new ideas for the diagnosis and treatment of PCOS.

关 键 词：多囊卵巢综合征 胰岛素抗药性 代谢疾病 Irisin 

分 类 号：R711.75[医药卫生—妇产科学]